NCT05062603

Brief Summary

Lung ultrasound has been used to help diagnose COVID-19 as an alternative to CT scanning and chest X-ray. CT scanning is onerous and there are difficulties taking critically unwell patients there as well as decontamination issues. Chest X-ray misses up to 40% of COVID diagnoses. Although lung ultrasound can diagnose, the investigators do not know how long these lung ultrasound changes last. The investigators would like to follow up patients to characterise the pattern of changes and how long they last. This is particularly important given a potential second surge of COVID-19 is looming and the investigators would like to know if lung ultrasound changes are new or old in patients presenting during this second wave and in the future.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
23

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jul 2020

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 9, 2020

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2020

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

September 29, 2021

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 30, 2021

Completed
Last Updated

October 8, 2021

Status Verified

September 1, 2021

Enrollment Period

5 months

First QC Date

September 29, 2021

Last Update Submit

September 30, 2021

Conditions

Covid19CoronavirusCoronavirus InfectionSARS-CoV Infection

Keywords

CoronavirusCOVID-19Lung ultrasoundRespiratory

Outcome Measures

Primary Outcomes (1)

  • Assessment of lung ultrasound changes over the time period of follow up.

    The assessment will determine how long it takes for lung ultrasound changes to resolve following discharge from hospital in patients who were diagnosed with COVID-19 (unit of measurement: days).

    Approximately 3 months or until the ultrasound changes in the lung had normalised

Secondary Outcomes (1)

  • Exploration of ongoing symptoms

    Approximately 3 months or until the ultrasound changes in the lung had normalised

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adults with a confirmed COVID-19 viral infection.

You may qualify if:

  • years old or older
  • Confirmed COVID-19 positive with changes on CXR or CT scan
  • Having had an initial lung ultrasound in the Emergency department when they were first admitted into the hospital.

You may not qualify if:

  • Pre-existing lung disease
  • Heart failure
  • Under 18 years old.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Chelsea and Westminster Hospital

London, Greater London, SW10 9NH, United Kingdom

Location

Related Publications (4)

  • Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS; China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.

    PMID: 32109013BACKGROUND

  • Poggiali E, Dacrema A, Bastoni D, Tinelli V, Demichele E, Mateo Ramos P, Marciano T, Silva M, Vercelli A, Magnacavallo A. Can Lung US Help Critical Care Clinicians in the Early Diagnosis of Novel Coronavirus (COVID-19) Pneumonia? Radiology. 2020 Jun;295(3):E6. doi: 10.1148/radiol.2020200847. Epub 2020 Mar 13. No abstract available.

    PMID: 32167853BACKGROUND

  • Huang Yi, Sihan Wangm Yue Liu, Yaohui Zhang, Chuyun Zheng, Yu Zheng, CHaoyang Zhangm et al. A preliminary study on the ultrasonic manifestations of Peripulmonary lesions of non-critical Novel Coronavirus Pneumonia (Covid-19).

    BACKGROUND

  • Peng QY, Wang XT, Zhang LN; Chinese Critical Care Ultrasound Study Group (CCUSG). Findings of lung ultrasonography of novel corona virus pneumonia during the 2019-2020 epidemic. Intensive Care Med. 2020 May;46(5):849-850. doi: 10.1007/s00134-020-05996-6. Epub 2020 Mar 12. No abstract available.

    PMID: 32166346BACKGROUND

MeSH Terms

Conditions

COVID-19Coronavirus InfectionsSevere Acute Respiratory Syndrome

Condition Hierarchy (Ancestors)

Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Study Officials

  • Paramjeet Deol, MBChB FRCEM

    Chelsea and Westminster NHS Foundation Trust

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 29, 2021

First Posted

September 30, 2021

Study Start

July 9, 2020

Primary Completion

December 1, 2020

Study Completion

December 1, 2020

Last Updated

October 8, 2021

Record last verified: 2021-09

Data Sharing

IPD Sharing
Will not share

Locations

GB(1)