LOng COvid Multidisciplinary Consortium: Optimising Treatments and servIces Across the NHS (LOCOMOTION)

NCT05057260 | Unknown DMC

• 1 other identifier: 303623
• Study Type: observational
• Target: 7,000
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Long Covid (LC) affects over one million people in the UK, it has various symptoms and impacts daily life. Although there are 83 LC clinics in England, most people have not had access to them, and waiting times to be seen are long. We realise the urgency for LC patients to access prompt and appropriate care in clinics and doctors' surgeries, as well as manage their symptoms effectively at home. Aim:Our research aims to produce a 'gold standard' for care by analysing what is happening to patients now, creating new systems of care and evaluating them to establish best practice. Outline Of Research: This research has been developed with LC patients and will continue to include patients working as equal partners. Key priorities of LC patients are: correct clinical assessment; advice and treatment; and help with returning to work and other roles. This research is also based on the experience of a wide range of NHS professionals already treating people in ten LC clinics across the UK, and led by academics (universities) with links to other LC funded studies. The research will take place in three settings: LC clinics; at home (including self-monitoring on a mobile device using a set of questions on symptoms built into an app); and in doctors' surgeries. We will track where patients are being referred or not referred, and learn from the experience of clinics by interviewing patients and recording outcomes. Throughout, specialists in 'Healthcare Inequality' will reach people who are not accessing clinics. We will put in place new processes in clinics and doctors' surgeries, monitored throughout to make sure they are the correct standard, accessible for patients and staff, and cost-effective. Outcomes: Comparing findings across our partnership of ten LC Clinics we will learn more about treatment, providing real-time education to other healthcare staff and patients, and establishing a 'gold standard' that can be shared within England and the rest of the UK.

Conditions

COVID-19

Outcome Measures

Primary Outcomes (2)

• European Quality of Life Five Dimensions

  Quality of Life VAS score min 0 max 100

  2 years

• COVID-19 Yorkshire Rehabilitation Scale

  Symptom severity (min 0 max 100) and functional disability (min 0 max 50) and health state (min 0 max 10)

  2 years

Study Arms (1)

Long Covid cohort

Long Covid patients managed in the 10 participating sites

Other: No drug invervention

Interventions

No drug invervention OTHER

No clinical trial

Long Covid cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients referred into one of the ten Long Covid services by their General Practitioner (GP), or other clinicians (Positive Antigen or Antibody test is not required.)

You may qualify if:

• Age 18 and over, receiving care for Long Covid symptoms at one of the participating LC sites.
• Willing and able to consent for their data to be used for research and/or service evaluation purposes. Consent will be gathered via patient information sheet and formal recording of consent (on the phone application).

You may not qualify if:

• Inability to independently complete electronic or paper-based outcome measures, questionnaires or other research-based paperwork.
• Unable to give Informed Consent.

Sponsors & Collaborators

• University of Leeds: lead
• Imperial College London: collaborator
• University of Oxford: collaborator
• University of Exeter: collaborator
• King's College London: collaborator
• University of Manchester: collaborator
• University of Dundee: collaborator
• Leeds Comunity Healthcare NHS Trust: collaborator
• Oxford University Hospitals NHS Trust: collaborator
• Imperial College Healthcare NHS Trust: collaborator
• University Hospitals, Leicester: collaborator
• Birmingham Community Healthcare NHS: collaborator
• NHS Tayside: collaborator
• Newcastle-upon-Tyne Hospitals NHS Trust: collaborator
• University Hospital of Wales: collaborator

Study Sites (1)

University of Leeds

Leeds, Yorkshire, LS1 3EX, United Kingdom

RECRUITING

Related Publications (6)

• Horton M, Smith AB, Milne R, Winch D, Rayner C, Halpin S, O'Connor R, Rocha Lawrence R, Greenwood DC, Bakerly ND, Evans R, Kwon J, Dawes H, Wood C, Williams P, Master H, Mansoubi M, De Kock JH, Mullard J, Ormerod M, Mir G, Petrou S, O'Connor DB, Sivan M; LOCOMOTION Consortium. Large-Scale Psychometric Assessment and Validation of the Modified COVID-19 Yorkshire Rehabilitation Scale Patient-Reported Outcome Measure for Long COVID or Post-COVID Syndrome. J Med Virol. 2026 Feb;98(2):e70816. doi: 10.1002/jmv.70816.

  PMID: 41586458 DERIVED

• Lee C, Williams P, Abrahams A, Darbyshire J, Davies HE, De Kock J, Esmer U, Jones SA, Newey V, Scott J, Smith N, Winch D, Master H, Elkin S; LOCOMOTION Consortium. What Can We Learn Four Years On? A Multi-Centre Service Evaluation Exploring Symptoms, Functional Impact, Recovery and Care Pathways in Long Covid. Health Expect. 2025 Dec;28(6):e70435. doi: 10.1111/hex.70435.

  PMID: 41199609 DERIVED

• Greenhalgh T, Darbyshire JL, Lee C, Ladds E, Ceolta-Smith J. What is quality in long covid care? Lessons from a national quality improvement collaborative and multi-site ethnography. BMC Med. 2024 Apr 15;22(1):159. doi: 10.1186/s12916-024-03371-6.

  PMID: 38616276 DERIVED

• Lee C, Greenwood DC, Master H, Balasundaram K, Williams P, Scott JT, Wood C, Cooper R, Darbyshire JL, Gonzalez AE, Davies HE, Osborne T, Corrado J, Iftekhar N, Rogers N, Delaney B, Greenhalgh T, Sivan M; LOCOMOTION Consortium. Prevalence of orthostatic intolerance in long covid clinic patients and healthy volunteers: A multicenter study. J Med Virol. 2024 Mar;96(3):e29486. doi: 10.1002/jmv.29486.

  PMID: 38456315 DERIVED

• Mullard JCR, Kawalek J, Parkin A, Rayner C, Mir G, Sivan M, Greenhalgh T. Towards evidence-based and inclusive models of peer support for long covid: A hermeneutic systematic review. Soc Sci Med. 2023 Mar;320:115669. doi: 10.1016/j.socscimed.2023.115669. Epub 2023 Jan 14.

  PMID: 36708608 DERIVED

• Sivan M, Greenhalgh T, Darbyshire JL, Mir G, O'Connor RJ, Dawes H, Greenwood D, O'Connor D, Horton M, Petrou S, de Lusignan S, Curcin V, Mayer E, Casson A, Milne R, Rayner C, Smith N, Parkin A, Preston N, Delaney B; LOCOMOTION consortium. LOng COvid Multidisciplinary consortium Optimising Treatments and servIces acrOss the NHS (LOCOMOTION): protocol for a mixed-methods study in the UK. BMJ Open. 2022 May 17;12(5):e063505. doi: 10.1136/bmjopen-2022-063505.

  PMID: 35580970 DERIVED

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Manoj Sivan, MD

  University of Leeds

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Manoj Sivan, MD

CONTACT

01133922564; m.sivan@leeds.ac.uk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor and Consultant in Rehabilitation Medicine

Study Record Dates

• First Submitted: September 23, 2021
• First Posted: September 27, 2021
• Study Start: January 18, 2022
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2024
• Last Updated: November 3, 2022

Record last verified: 2022-10

Locations

GB (1)