Factors Associated With Mortality, Morbidity and Prognosis in Dementia Patients

NCT05052450 | Completed

• 1 other identifier: 2021/290
• Study Type: observational
• Target: 1,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Dementia; It is a chronic syndrome characterized by a general and progressive deterioration in cognition, including memory, orientation, language, and comprehension. The prognosis of this progressive and neurodegenerative disease after diagnosis may differ between individuals. In its broadest sense, the prognosis after a diagnosis of dementia; can be defined by shortening of life span, high level of cognitive and functional loss, decrease in quality of life and increased need for care. However, the prognosis of different types of dementia is highly variable. Because it is the most common type of dementia, studies are usually on Alzheimer's disease. It constitutes 50-75% of total dementia cases. Vascular dementia is the second most common cause of dementia and accounts for approximately 15% of dementia cases. Dementia with Lewy bodies constitutes 10-20% of the total dementia patients and ranks second among degenerative dementia types. Frontotemporal dementia, which mimics psychiatric disorders and has prominent behavioural problems, and Parkinson's disease-associated dementia, which is characterized by cognitive impairment that can be added to the existing picture in Parkinson's patients, are also counted among other types of dementia. Prognosis-related data on dementia types other than Alzheimer's disease are limited in the literature. Determining the prognosis is important to support patients, anticipate long-term health problems, plan physician and healthcare provision, and support patients with dementia.In view of the lack of sufficient data on dementia types other than Alzheimer's disease, it is aimed to contribute to the literature on this subject and to determine the factors that may affect prognosis, morbidity and mortality in patients belonging to all dementia types.

Conditions

Dementia; Dementia, Vascular; Dementia With Lewy Bodies; Dementia of Alzheimer Type; Dementia Frontal; Dementia, Mixed

Outcome Measures

Primary Outcomes (3)

• Mortality

  The event of death occuring during the follow-up period

  2 years

• Mini-Mental State Examination

  It was performed to assess mental status. It gives an overall opinion on cognitive domains and tests orientation, registration, attention and calculation, recall, and language. Total scores on Mini-Mental State Examination range from 0 to 30, higher scores show better cognitive performance.

  2 years

• Barthel Index

  It was used for assessing physical functioning as a part of the routine geriatric evaluation.where the ten performance items used. Those items defined as feeding, bathing, grooming, dressing, continence of bowel and bladder, toilet use, transfers (bed to chair and back), mobility (on level surfaces), and climbing stairs. Each item is scored on this scale, and the sum is obtained by adding the score of each item (range, 0-100; higher scores show better performance)

  2 years

Study Arms (5)

Dementia with Alzheimer

Patients previously diagnosed with Alzheimer disease would be included

Other: Observational

Dementia with Lewy Body Dementia

Patients previously diagnosed with Lewy Body Dementia would be included

Other: Observational

Dementia with Fronto-Temporal Dementia

Patients previously diagnosed with Fronto-Temporal Dementia would be included

Other: Observational

Dementia with Vascular Disease

Patients previously diagnosed with Dementia with Vascular Disease would be included

Other: Observational

Dementia with Parkinson Disease

Patients previously diagnosed with Dementia with Parkinson Disease would be included

Other: Observational

Interventions

Observational OTHER

Patients data were collected throughout the following time

Dementia with Alzheimer; Dementia with Fronto-Temporal Dementia; Dementia with Lewy Body Dementia; Dementia with Parkinson Disease; Dementia with Vascular Disease

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients diagnosed with any kind of dementia and being older than 60 years would be included in the study

You may qualify if:

• Having applied to the Gulhane Training and Research Hospital Geriatrics Polyclinic Being diagnosed with Alzheimer or Lewy Body Dementia or Vascular Dementia or Fronto-Temporal Dementia or Parkinson Disease Dementia Being at the age of 60 years or older

You may not qualify if:

• Being under the age of 60 Patients with insufficient recorded data and follow-up for the study Patients who either have diagnosis or follow-up in another center. Patients who have severe dementia that prevents applying for outpatient clinic

Sponsors & Collaborators

• Gulhane Training and Research Hospital: lead

Related Publications (1)

• Naharci MI, Kayahan Satis N, Ozsurekci C, Tasci I. Assessment of clinical features and coexisting geriatric syndromes in newly diagnosed dementia with Lewy bodies: a retrospective study in a tertiary geriatrics setting in Turkey. Eur Geriatr Med. 2023 Feb;14(1):19-27. doi: 10.1007/s41999-022-00727-0. Epub 2022 Dec 13.

  PMID: 36512254 DERIVED

MeSH Terms

Conditions

Dementia; Dementia, Vascular; Lewy Body Disease; Mixed Dementias

Interventions

Watchful Waiting

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Cerebrovascular Disorders; Intracranial Arteriosclerosis; Intracranial Arterial Diseases; Leukoencephalopathies; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Outcome Assessment, Health Care; Outcome and Process Assessment, Health Care; Quality of Health Care; Health Services Administration

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: September 8, 2021
• First Posted: September 22, 2021
• Study Start: January 1, 2000
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2020
• Last Updated: September 22, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share