Association of the Neutrophil/Lymphocyte Ratio With Pulmonary Complications and Mortality in COVID-19 Patients

NCT05052346 | Completed DMC

• 1 other identifier: NR-09-2020
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The Coronavirus Disease-19 (COVID-19) pandemic is currently a priority for health services worldwide. Unlike the Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) epidemic in 2012, the COVID-19 shows specific alterations in the white blood cell count, accentuated in severe cases, and with respiratory failure. Among the most relevant data are both lymphopenia, thrombocytopenia, and eosinopenia. The Neutrophil Lymphocyte Index has been beneficial in the evaluation of infectious respiratory processes, showing a sensitivity similar to scales such as CURB65 (Confusion, Uremia, Respiratory rate, BP, age ≥ 65 years). Because COVID-19 infection shows alterations in the blood cell ratio, these indices may be useful in evaluating patients with COVID-19 infection.

Conditions

Covid19; Pulmonary Complication

Keywords

Pulmonary Complications; Mortality; COVID-19; Neutrophil/Lymphocyte Ratio

Outcome Measures

Primary Outcomes (2)

• Respiratory Complications in COVID-19 patients

  To assess the relationship of the Neutrophil-Lymphocyte and Lymphocyte-Platelet index on respiratory complications

  6 months

• Mortality in COVID-19 patients

  To assess the relationship of the Neutrophil-Lymphocyte and Lymphocyte-Platelet index on respiratory complications

  6 months

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Mexican patients diagnosed with active COVID-19 infection who require hospital care and who have peripheral blood counts at diagnosis.

You may qualify if:

• Patients with active COVID-19 infection

You may not qualify if:

• Liver failure
• Active cancer
• Chronic renal failure
• AIDS
• Pregnancy

Sponsors & Collaborators

• Hospital General de Mexico: lead

Study Sites (1)

Omar Ramos-Peñafiel

Mexico City, 06726, Mexico

Location

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Adolfo Martinez Tovar

  Hospital General de Mexico

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Month
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 31, 2020
• First Posted: September 22, 2021
• Study Start: March 30, 2020
• Primary Completion: May 5, 2020
• Study Completion: May 15, 2020
• Last Updated: September 22, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

ME (1)