NCT05051384|Active Not Recruiting
Superb Microvascular Intraocular Tumor Imaging Study (SMITIS)
SMITIS
Using the Superb Microvascular Imaging Method in the Diagnosis of Intraocular Tumors (SMITIS)
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SMITIS
Using the Superb Microvascular Imaging Method in the Diagnosis of Intraocular Tumors (SMITIS)
Sponsor study identifier
Secondary identifiers
OTHER · ANSM
interventional
22
1 country
1
Study Start
April 27, 2022
Actual (reported)Primary Completion
April 27, 2023
Actual (reported)Study Completion
January 18, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The diagnosis and monitoring of intraocular tumors are based on multimodal imaging in addition to the clinical examination (ultra-widefield retinal imaging, echography, angiography). Nevertheless, it may be difficult in cases of retinal hemorrhage, small tumor size or atypical presentation. The study of microvascular flow (Superb Microvascular Imaging, SMI) of intraocular tumors could improve the confidence of differential diagnosis when evaluating these suspicious lesions, or even determine whether a lesion is benign or malignant by describing the vascularization of the lesion. The investigators propose to study the microvascular flow patterns of intraocular tumors prior to proton therapy.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 18, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 20, 2021
Actual (reported)September 21, 2021
Actual (reported)April 27, 2022
Actual (reported)April 27, 2023
Actual (reported)January 18, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Qualitative description of the intratumoral microvascular flow
Number of visible feeding pedicles
Visite 2 - two weeks after Day 0
Qualitative description of the intratumoral microvascular flow
Number of visible feeding pedicles
Month 6
quantification of microvascular flow for each tumor
Visite 2 2weeks after Day 0
quantification of microvascular flow for each tumor
month 6
New sonographic software technique on ultrasonography to detect low-vascular flow inside intraocular tumors
The study of tumor vascularization can help in the differential diagnosis and follow-up of tumors, and therefore can impact the management of patients with tumors
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
CHU de Nice
Nice, France, 06000, France
Sacha NAHON ESTEVE
Centre Hospitalier Universitaire de Nice
22 participants (actual enrollment reported by the registry).
First Submitted
August 20, 2021
First Posted
September 21, 2021
Study Start
April 27, 2022
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
April 27, 2023
Actual (reported)Study Completion
January 18, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
December 3, 2025
Record last verified: 2025-11
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Source: ClinicalTrials.gov.
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