Blood Gases Versus Lactate Clearance as an Indicator of Initial Resuscitation in Septic Patients: Comparative Study

NCT05049941 | Unknown

• 1 other identifier: 6382021
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

\- This perspective blind randomized single center study was designed to assess central venous and arterial gases level including P(v-a)CO2/C(a-v)O2 ratio and P(v-a)CO2 difference against lactate clearance as an indicator of initial resuscitation in septic patients in intensive care unit and to evaluate the success of early resuscitation protocol .this continuation of our previous work we compared the ratio of P(v-a)CO2/C(a-v)O2 ratio against lactate clearance(8). Mortality in the ICU in the study groups will be recorded

Conditions

Sepsis Syndrome

Outcome Measures

Primary Outcomes (1)

• in septic patients in intensive care unit and to evaluate the success of early resuscitation protocol

  success of early resuscitation

  3-4 monthes

Study Arms (3)

group1

Group (1): veno-arterial carbon dioxide tension / arteriovenous oxygen content P(v-a)CO2/C(a-v)O2 ratio group.

Diagnostic Test: lactat and blood gases

group 2

Group (2): Lactate clearance (LC) group; Lactate level was measured then LC rate was calculated by the equation \[(lactate(T0)- lactate(T8))/lactate(T0)\] × 100%.

Diagnostic Test: lactat and blood gases

group 3

Group (3): veno-arterial carbon dioxide tension group; P(v-a)co2 difference

Diagnostic Test: lactat and blood gases

Interventions

lactat and blood gases DIAGNOSTIC_TEST

observational

group 2; group 3; group1

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

120 adult critically ill patients admitted to the ICU in Minia University Hospital. Patients Ages was ≥ 18 and ≤ 65 years including both sexs, resuscitation started after fulfilling the diagnostic criteria of sepsis issued by Surviving Sepsis Campaign 2016

You may qualify if:

• adult critically ill patients admitted to the ICU in Minia University Hospital. Patients Ages was ≥ 18 and ≤ 65 years including both sexs, resuscitation started after fulfilling the diagnostic criteria of sepsis issued by Surviving Sepsis Campaign 2016

You may not qualify if:

• We excluded Patients with chronic organ failure (Cardiovascular, Respiratory, Liver, Neurological and Renal.)

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Ahmed Hassanein

Minya, 11116, Egypt

RECRUITING

MeSH Terms

Conditions

Systemic Inflammatory Response Syndrome

Interventions

Blood Gas Analysis

Condition Hierarchy (Ancestors)

Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Intervention Hierarchy (Ancestors)

Blood Chemical Analysis; Clinical Chemistry Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Investigative Techniques

Study Officials

• ahmed hassanein, MD

  Minia University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

ahmed hassanein, MD

CONTACT

01006946879; ahmedhassanein10@yahoo.com

rehab mohamed, MD

CONTACT

01004407515; rehabmahamed820@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: September 9, 2021
• First Posted: September 20, 2021
• Study Start: August 15, 2021
• Primary Completion: November 15, 2021
• Study Completion: December 15, 2021
• Last Updated: September 20, 2021

Record last verified: 2021-09

Locations

EG (1)