Therapeutic Effects of Topical Herbal Medicine -Rhubarb Ointment on Rosacea
1 other identifier
interventional
24
1 country
1
Brief Summary
The aim of this study is to investigate the effects of topical herbal medicine in the patients with rosacea.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_2
Started Aug 2021
Typical duration for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 4, 2021
CompletedFirst Submitted
Initial submission to the registry
September 7, 2021
CompletedFirst Posted
Study publicly available on registry
September 16, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 23, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
August 4, 2024
CompletedResults Posted
Study results publicly available
April 1, 2025
CompletedApril 1, 2025
January 1, 2024
2.8 years
September 7, 2021
February 16, 2025
March 13, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Reduction of Flushing, Erythema, Telangiectasia, Papules, and Pustules
quantified by Investigator Global Assessment, IGA. IGA is used in the study for assessing the severity of rosacea ranging from 0 (clean) to 4 (most severe).
6 weeks
Secondary Outcomes (1)
Dermatology Quality of Life Index, DQoL
6 weeks
Study Arms (2)
group A (dian dao san group)
ACTIVE COMPARATORHerbal medicine (dian dao san) will be applied to the lesions of rosacea twice a day. Subject will receive persistent treatment for 6 weeks.
group B( topical medicine without therapeutic effects)
PLACEBO COMPARATORPlacebo (topical medicine without therapeutic effects) will be applied to the lesions of rosacea twice a day. Subject will receive persistent treatment for 6 weeks.
Interventions
dian dao san and placebo will be used in the rosacea lesions twice a day for 6 weeks
Eligibility Criteria
You may qualify if:
- Willing to sign inform consent
- Aged above 20 years old with rosacea
- No treatment for rosacea within 2 weeks
You may not qualify if:
- With malignant lesion in the rosacea lesion
- Rosacea lesion with high risk of infection
- Allergy to Chinese herbal medicine patch or ointment
- Pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Keelung Chang Gung Memorial Hospital
Keelung, Taiwan
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. HuanHsuan Hsu
- Organization
- CGMH
Study Officials
- PRINCIPAL INVESTIGATOR
YUAN-CHIEH YEH, Doctor
Chang Gung Memorial Hospital
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 7, 2021
First Posted
September 16, 2021
Study Start
August 4, 2021
Primary Completion
May 23, 2024
Study Completion
August 4, 2024
Last Updated
April 1, 2025
Results First Posted
April 1, 2025
Record last verified: 2024-01