Releasing of Inflammatory Mediators During Retreatment of Root Canals

NCT05039502 | Completed

• 1 other identifier: 2020-27194235-01
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region

Conditions

Inflammatory Response; Root Canal Infection

Outcome Measures

Primary Outcomes (1)

• change of inflammatory mediator level

  The samples were collected from periapical exudate at the end of the root canal retreatment procedure. The samples were analyzed with ELISA method and change of inflammatory mediator levels were evaluated in pg/ml.

  24 hours

Study Arms (3)

Retreatment system using in rotational motion

EXPERIMENTAL

Previous root canal filling materials were removed with D1-D2-D3 retreatment files with using an endodontic motor in rotational motion

Other: Protaper Universal Retreatment

Retreatment system using in reciprocal motion

EXPERIMENTAL

Previous root canal filling materials were removed with Reciproc 25 file with using an endodontic motor in reciprocal motion

Other: Reciproc

Retreatment system using in additional rotational motion

EXPERIMENTAL

Previous root canal filling materials were removed with XP-endo finisher r file with using an endodontic motor in rotational motion

Other: XP-Endo finisher R

Interventions

Protaper Universal Retreatment OTHER

D1-D2-D3 Retreatment files were used in 500 rpm and 3 Ncm with X-Smart endomotor

Retreatment system using in rotational motion

Reciproc OTHER

R25 retratment files were used with X-Smart endomotor in reciprocal motion

Retreatment system using in reciprocal motion

XP-Endo finisher R OTHER

XP-Endo finisher r file were used in 1000 rpm 1 Ncm with X-Smart endomotor

Retreatment system using in additional rotational motion

Eligibility Criteria

• Age: 18 Years - 68 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who had single root canal treated teeth with chronic periapical lesion

You may not qualify if:

• Patients who are immunocompromised
• Patients under antibiotic or analgesic medication

Sponsors & Collaborators

• Bulent Ecevit University: lead

Study Sites (1)

Faculty of Dentistry of Bulent Ecevit University

Zonguldak, Turkey (Türkiye)

Location

Related Publications (1)

• Kasikci S, Turker SA, Guven B. Effect of different retreatment files using different kinematics on the release of inflammatory mediators in root canal retreatment of single-rooted teeth: a randomized clinical trial. Clin Oral Investig. 2023 Jun;27(6):3189-3196. doi: 10.1007/s00784-023-04930-6. Epub 2023 Mar 1.

  PMID: 36856848 DERIVED

Study Officials

• Sevinç Aktemur Türker

  Bulent Ecevit University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 31, 2021
• First Posted: September 9, 2021
• Study Start: October 1, 2020
• Primary Completion: March 15, 2021
• Study Completion: June 1, 2021
• Last Updated: September 9, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)