Hirschsprung Disease Trends in the United States: Analysis of the National Inpatient Sample

NCT05038345 | Terminated

• 1 other identifier: 18-697
• Study Type: observational
• Target: 2,787
• Locations: 1 country
• Sites: 1

Brief Summary

Hirschsprung disease (HD) is associated with significant morbidities including long-term bowel dysfunction. The aim of this study was to update national and regional trends in the epidemiology and inpatient care utilization of HD in the United States between 2009 and 2014 using the National Inpatient Sample (NIS).

Conditions

Hirschsprung Disease

Outcome Measures

Primary Outcomes (1)

• The primary objective of this study was to analyze cost of HD-related admissions in the United States between 2009 and 2014 using the National Inpatient Sample (NIS) database.

  2009 to 2014.

Interventions

Pull through surgery PROCEDURE

The principal purpose of pull through surgery for Hirschsprung disease is to remove aganglionic bowel and reconstruct the intestinal tract by connecting the normally innervated bowel just above the anus so that normal sphincter function is preserved.

Eligibility Criteria

• Age: 1 Day - 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

We included all patients who were 18 years or younger with an ICD-9-CM code of 751.3 for HD among the first 10 diagnosis. Patients whose discharge disposition was transfer to another hospital were excluded to avoid over-counting. We identified patients with a pull-through procedure using following ICD-9-CM codes: 4592, 4593, 4594, 4595, 4840, 4841, 4842, 4843, 4849, and 4865. We tracked the number of these pull-through procedures a patient received. We used all 15 procedure codes to identify pull-through procedures and other procedures. To identify common discharge diagnoses we used the first five diagnosis codes. To identify congenital anomalies we used all diagnosis codes.

You may qualify if:

• We included all patients who were 18 years or younger with an ICD-9-CM code of 751.3 for HD among the first 10 diagnosis.

You may not qualify if:

• Data from 2015 to 2018 were not included since diagnoses and procedures were reported using the ICD-10-CM coding system.

Sponsors & Collaborators

• University of New Mexico: lead

Study Sites (1)

University of New Mexico

Albuquerque, New Mexico, 87106, United States

Location

Related Publications (2)

• Huang EY, Tolley EA, Blakely ML, Langham MR. Changes in hospital utilization and management of Hirschsprung disease: analysis using the kids' inpatient database. Ann Surg. 2013 Feb;257(2):371-5. doi: 10.1097/SLA.0b013e31827ee976.

  PMID: 23263193 BACKGROUND

• Dharmaraj R, Reno J, Fridge J, Perger L, Zhu Y. Inpatient Care Utilization and Epidemiology of Hirschsprung Disease: Analysis of the National Inpatient Sample. J Pediatr Gastroenterol Nutr. 2022 Jul 1;75(1):3-9. doi: 10.1097/MPG.0000000000003449. Epub 2022 May 27.

  PMID: 35622006 DERIVED

MeSH Terms

Conditions

Hirschsprung Disease

Condition Hierarchy (Ancestors)

Digestive System Abnormalities; Digestive System Diseases; Megacolon; Colonic Diseases; Intestinal Diseases; Gastrointestinal Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Yiliang Zhu

  University of New Mexico

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD Assistant Professor

Study Record Dates

• First Submitted: August 31, 2021
• First Posted: September 9, 2021
• Study Start: March 13, 2019
• Primary Completion: August 15, 2021
• Study Completion: August 15, 2021
• Last Updated: February 24, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)