Cardiac MRI for the Detection of Myocardial Injury Following Acute Kidney Injury
Multiparametric Cardiac MRI for the Detection and Quantification of Myocardial Injury Following Acute Kidney Injury (Cardiorenal Syndrome Type 3)
1 other identifier
observational
40
1 country
2
Brief Summary
The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay by multiparametric cardiac MRI.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Apr 2021
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 7, 2021
CompletedFirst Submitted
Initial submission to the registry
August 27, 2021
CompletedFirst Posted
Study publicly available on registry
September 5, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2023
CompletedSeptember 5, 2021
September 1, 2021
1.3 years
August 27, 2021
September 2, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Myocardial T1 relaxation time
T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\].
Measurement will be performed within 2 weeks after MRI scan.
Secondary Outcomes (3)
Myocardial T2 relaxation time
Measurement will be performed within 2 weeks after MRI scan.
Myocardial ECV
Measurement will be performed within 2 weeks after MRI scan.
Myocardial strain
Measurement will be performed within 2 weeks after MRI scan.
Study Arms (2)
Intensiv care patients after acute kidney injury
Patients with condition after intensive care stay and acute kidney injury and subsequent convalescence (without preexisting underlying cardiac disease or other disease with potential cardiac involvement).
Intensiv care patients without kidney injury
Patients with condition after intensive care stay and subsequent convalescence (without kidney injury and preexisting underlying cardiac disease or other disease with potential cardiac involvement).
Interventions
Multiparametric cardiac magnetic resonance, including functional and structural parameter
Eligibility Criteria
Patients with convalescence after acute renal failure who were/are treated in the Department of Anesthesiology and Intensive Care Medicine of the University Hospital Bonn are included.
You may qualify if:
- acute kidney injury and convalescence (GFR \> 45 ml/min/1.73m²).
- patients who are 18 years of age or older
You may not qualify if:
- underlying cardiac disease, e.g. known myocardial infarction, previous myocarditis, congenital heart disease, cardiomyopathies of other causes
- known underlying disease wit potential cardiac involvement, e.g. storage disease (e.g. hemochromatosis, Fabry disease), inflammatory (e.g. sarcoidosis), endocrinological (e.g. diabetes mellitus, hyper-/hypothyroidism), autoimmune (e.g. systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis), therapeutic (chemotherapy).
- patients with persistent renal failure and GFR \< 45 ml/min/1.73m²
- allergy to contrast media
- patients who are using a intrauterinpessare for contraception
- pregnant and breastfeeding women
- patients with contraindications for MRI due to implants
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology
Bonn, North Rhine-Westphalia, 53127, Germany
University Hospital Bonn, Department of Anesthesiology and Intensive Care Medicine
Bonn, North Rhine-Westphalia, 53127, Germany
Related Publications (1)
Isaak A, Pomareda I, Mesropyan N, Kravchenko D, Endler C, Bischoff L, Pieper CC, Kuetting D, Attenberger U, Zimmer S, Putensen C, Schewe JC, Kreyer S, Luetkens JA. Cardiovascular Magnetic Resonance in Survivors of Critical Illness: Cardiac Abnormalities Are Associated With Acute Kidney Injury. J Am Heart Assoc. 2023 May 2;12(9):e029492. doi: 10.1161/JAHA.123.029492. Epub 2023 Apr 29.
PMID: 37119085DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator, Senior Physician
Study Record Dates
First Submitted
August 27, 2021
First Posted
September 5, 2021
Study Start
April 7, 2021
Primary Completion
July 31, 2022
Study Completion
December 31, 2023
Last Updated
September 5, 2021
Record last verified: 2021-09
Data Sharing
- IPD Sharing
- Will not share