Healing Effect of Ziziphus Honey on Extracted Tooth Socket in Humans by Evaluating the Levels of BMP-2 and OPN

NCT05025306 | Completed Phase 3

• 1 other identifier: PGMILahore
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Ziziphus honey can improve bone healing at extracted tooth sockets in humans by increasing salivary levels of bone markers, OPN and BMP-2.

Conditions

Healing Wound

Outcome Measures

Primary Outcomes (3)

• levels of BMP-2

  bone morphogenetic protein-2 levels to access amount of bone healing

  1 week

• levels of OPN

  Osteopontin levels to access amount of bone healing

  1 week

• Relative bone density

  bone quality confirmed on periapical radiographs in both groups

  40 days

Study Arms (2)

control group

NO INTERVENTION

only atraumatic extractions were done, honey was not applied

experimental group

EXPERIMENTAL

ziziphus honey was applied into the sockets after tooth extractions in experimental group

Drug: ziziphus honey

Interventions

ziziphus honey DRUG

ziziphus honey obtained form ziziphus spina-christi trees also called sidr tree

Also known as: sidr honey, honey

experimental group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy patients of either gender with adult age
• No known hypersensitivity to honey.
• Permanent maxillary or mandibular molars (first or second molars)

You may not qualify if:

• History of radiotherapy or chemotherapy
• Diabetic and hypertensive patients.
• Pregnant and lactating females.
• Smoking or consumption of alcohol
• Bone conditions like osteoporosis etc.
• Patients on oral contraceptives or steroid therapy
• Subjects taking antibiotics or NSAIDS within one week.

Sponsors & Collaborators

• Postgraduate Medical Institute, Lahore: lead

Study Sites (1)

Post graduate medical institute, Lahore

Lahore, Punjab Province, 54000, Pakistan

Location

Related Publications (1)

• Mendes RM, Silva GA, Lima MF, Calliari MV, Almeida AP, Alves JB, Ferreira AJ. Sodium hyaluronate accelerates the healing process in tooth sockets of rats. Arch Oral Biol. 2008 Dec;53(12):1155-62. doi: 10.1016/j.archoralbio.2008.07.001. Epub 2008 Aug 9.

  PMID: 18692778 BACKGROUND

Related Links

• bone healing assessed through BMP-2 and OPN

MeSH Terms

Interventions

Honey

Intervention Hierarchy (Ancestors)

Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Momina Khalid, BDS

  PGMI, Lahore

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants were not aware of the intervention used
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Model Details: randomized controlled trial with simple random sampling technique

Study Record Dates

• First Submitted: August 23, 2021
• First Posted: August 27, 2021
• Study Start: January 1, 2020
• Primary Completion: March 16, 2020
• Study Completion: June 1, 2020
• Last Updated: September 1, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)