Investigation of Functional Brain Network in Altered Meditation State With Multimodal Neuroimaging

NCT05020301 | Completed

• 1 other identifier: B20200361
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate functional brain network in altered meditation state with multimodal neuroimaging.

Conditions

Meditation; Mindfulness

Keywords

mindfulness; functional brain network; neuroimaging; meditation

Outcome Measures

Primary Outcomes (3)

• Five Facet Mindfulness Questionnaire(FFMQ)

  FFMQ is a validated, self-administered questionnaire that measures the tendency to act with mindfulness. Its 39 items are assessed on a Likert scale from 1 to 5 (i.e., "never or very rarely true" to "very often or always true"). The higher scores on the scale convey the higher tendency to act with mindfulness.

  Week 1

• CSF pulsation index

  CSF pulsation index, calculated by the number of CSF pulsation per minute.

  Week 1

• Functional connectivity

  Checking functional connectivity in major resting-state brain networks (such as DMN).

  Week 1

Secondary Outcomes (5)

• Mindfulness positive awareness examined by Mindful Attention Awareness Scale (MAAS)

  Week 1

• The ability of self-compassion examined by Self-Compassion Scale(SCS) after 1-week practice of internal and external mindfulness

  Week 1

• Cognitive Flexibility Inventory(CFI)

  Week 1

• Perceived Stress Scale(PSS)

  Week 1

• The Chinese version of Freiburg Mindfulness Inventory(FMI-13)

  Week 1

Other Outcomes (4)

• Cognitive impairment quantitative assessment by Mini-Mental State Examination(MMSE)

  Week 0

• Intelligence assessment by Raven's Standard Progressive Matrices (SPM)

  Week 0

• Brief Profile of Mood States(Brief-POMS)

  Week 1

Study Arms (2)

Novice meditators

EXPERIMENTAL

Participants who have no meditation practice in the previous year and less than 20 entire lifetime hours' meditation.

Device: external meditation guided audio; Device: internal meditation guided audio

Experienced meditators

EXPERIMENTAL

Participants with more than two years of mindfulness practice

Device: external meditation guided audio; Device: internal meditation guided audio

Interventions

external meditation guided audio DEVICE

Examining DMN connectivity and CSF flow in external meditation state by External Meditation Instruction Audio.

Experienced meditators; Novice meditators

internal meditation guided audio DEVICE

Examining DMN connectivity and CSF flow in external meditation state by Internal Meditation Instruction Audio.

Experienced meditators; Novice meditators

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• A sufficient level of education to understand study procedure and be able to communicate with site personnel.
• years old.
• Interested in meditation.
• No metal or electronic implants in the body; no prosthesis (metal braces, dentures, etc.); no claustrophobia; no tattoos, piercings, etc.; no makeup on the day of the experiment.
• Right-handed.

You may not qualify if:

• The participant has a contraindication to MRI examination, such as claustrophobia.
• The participant is physically unfit for MRI, such as having a metal implant.
• The participant has a history of neurological or psychiatric disorders, or is taking any chronic medications that may interfere with the experiment.

Sponsors & Collaborators

• Shanghai Mental Health Center: lead
• School of Biomedical Engineering, Shanghai Jiao Tong University: collaborator

Study Sites (1)

School of Biomedical Engineering, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, 200030, China

Location

Study Officials

• Qing Fan

  Shanghai Mental Health Center

  STUDY CHAIR

• Jie Luo

  School of Biomedical Engineering, Shanghai Jiao Tong University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 14, 2021
• First Posted: August 25, 2021
• Study Start: September 20, 2020
• Primary Completion: December 30, 2023
• Study Completion: December 30, 2023
• Last Updated: July 23, 2026

Record last verified: 2021-06

Locations

CN (1)