Surgical Site Infections at a West Cameroon Hospital

NCT05018884 | Completed

• 1 other identifier: SSI Mbouo
• Study Type: observational
• Target: 148
• Locations: 1 country
• Sites: 1

Brief Summary

Surgical site infections (SSI) constitute an important health concern in low and middle income countries, leading to prolonged hospital stay and increased costs. Previous studies indicate that in Africa up to 1/3 of patients undergoing surgery may be affected by a postoperative infection. The development and implementation of context-specific SSI prevention guidelines is important to reduce this complication. To deploy efficient context-specific measures, data on epidemiology and microbiology of these infections are needed. This means to adapt the prevention measures to the context-specific risk factors for surgical site infections in resource-limited settings, and to give locally adapted recommendations on antimicrobial therapy based on local resistance patterns. However, data in this respect are scarce in low and middle income countries. This present study will contribute to the needed epidemiology and microbiology data on SSI in Cameroon. It will be carried out as a prospective cohort study at the Mbouo Protestant hospital in the West Region of Cameroon. The incidence, microbial spectrum and respective antimicrobial resistance of SSI as well as the risk factors of SSI will be systematically investigated. The study will include 300 patients at the Hôpital Protestant de Mbouo (HPM) who underwent surgery and gave their informed consent for inclusion, the timeframe is 04/2021 - 11/2021. An active SSI surveillance system will be put in place for 30 postoperative days to diagnose SSI. Expected outcomes: The incidence of SSI is likely to be higher than 10%. Concerning risk factors, preoperative bodywashing and perioperative antibioprophylaxis is expected to be protective against SSI. Up to 1/3 of SSI are expected to occur after hospital discharge. For the microbial spectrum, a high proportion of Staphylococcus aureus is likely to be found. For the antimicrobial resistance no estimation can be give as data is non-existent in that region from the literature.

Conditions

Surgical Wound Infection

Outcome Measures

Primary Outcomes (1)

• Incidence of Surgical Site Infections (SSI)

  The incidence of SSI of all patients included in the study

  04 / 2021 - 11 / 2021

Secondary Outcomes (3)

• Risk factors of SSI

  04 / 2021 - 11 / 2021

• Microbial spectrum of SSI

  04 / 2021 - 11 / 2021

• Post-operative mortality

  04 / 2021 - 11 / 2021

Study Arms (2)

Patients without SSI

Patients who underwent surgery and who developed a surgical site infection (SSI) during 30 days after surgery

Patients with SSI

Patients who underwent surgery and who didn't develop a surgical site infection (SSI) during 30 days after surgery

Procedure: Observation of surgical site infections

Interventions

Observation of surgical site infections PROCEDURE

No intervention is done, only observation of routine clinical practice

Patients with SSI

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients that receive surgery at the Hôpital Protestant de Mbouo in Cameroon and that are willing and consenting to participate in the study

You may qualify if:

• Patient underwent surgery at the hospital during study period

You may not qualify if:

• Unconscious patients, mentally ill patients

Sponsors & Collaborators

• Christian Doll: lead
• Charite University, Berlin, Germany: collaborator

Study Sites (1)

Hôpital Protestant de Mbouo

Bafoussam, West Region, 948, Cameroon

Location

Related Publications (1)

• Doll C, Ndoho Simo LC, Jeulefack H, Tamuedjoun Talom A, Kuate Kamdem L, Kenmogne JB, Djeunang Dongho GB, Trampuz A. Efforts in surgical site infection surveillance at the Mbouo Protestant Hospital in Cameroon. BMC Surg. 2025 Oct 3;25(1):419. doi: 10.1186/s12893-025-03229-5.

  PMID: 41044533 DERIVED

MeSH Terms

Conditions

Surgical Wound Infection

Condition Hierarchy (Ancestors)

Wound Infection; Infections; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Christian Doll, Dr

  Université Evangélique du Cameroun, Cameroon; Hôpital Protestant de Mbouo, Cameroon; Charité University Medical Centre Berlin, Germany; University Medical Centre Jena, Germany

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Dr. med. Christian Doll

Study Record Dates

• First Submitted: August 17, 2021
• First Posted: August 24, 2021
• Study Start: April 26, 2021
• Primary Completion: February 4, 2022
• Study Completion: February 4, 2022
• Last Updated: March 16, 2022

Record last verified: 2022-03

Locations

CA (1)