The Effect of Vitamin C on GCF Total Oxidant Capacity in Smoker Patients With Periodontitis
The Effect of Vitamin C Supplementation on GCF Total Oxidant Capacity in Smoker Patients With Periodontitis Following Non-surgical Periodontal Therapy. A Randomized Controlled Clinical Trial
1 other identifier
interventional
40
1 country
1
Brief Summary
The effect of vitamin C supplementation on GCF total oxidant capacity in smoker patients with periodontitis following non-surgical periodontal therapy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for early_phase_1
Started Jan 2019
Longer than P75 for early_phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 11, 2019
CompletedFirst Submitted
Initial submission to the registry
August 2, 2021
CompletedFirst Posted
Study publicly available on registry
August 17, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 21, 2022
CompletedMarch 7, 2022
March 1, 2022
2.7 years
August 2, 2021
March 4, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Total Oxidant Capacity
unit
one month
Secondary Outcomes (3)
Gingival index
one month
plaque index
one month
probing depth
one month
Study Arms (2)
experimental
EXPERIMENTALA Group: Consisted of 20 patients who were treated with scaling and root planing in conjunction with 2g antioxidant Vit (C)
Control
NO INTERVENTIONA Group: consisted of 20 patients who were treated with scaling and root planing.
Interventions
Eligibility Criteria
You may qualify if:
- all patients were systemically healthy
- stage III-IV grade B periodontitis
- A minimum of two non-adjacent teeth having sites with ≥ 5 mm interdental clinical attachment loss .
- Radiographic bone loss extending to middle third of root and beyond .
- All patients were heavy smokers i.e ≥ 20 cigarettes / day .
You may not qualify if:
- patients who had received any periodontal or antibiotic treatment or vitamins supplementation during the last six months.
- pregnant or lactating women
- patients who refused to provide written informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
Study Sites (1)
Abeer Hassan Sharafuddin
Cairo, Egypt
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
abeer H Sharafuddin, PhD
Cairo University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- early phase 1
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- lecturer
Study Record Dates
First Submitted
August 2, 2021
First Posted
August 17, 2021
Study Start
January 11, 2019
Primary Completion
September 30, 2021
Study Completion
December 21, 2022
Last Updated
March 7, 2022
Record last verified: 2022-03
Data Sharing
- IPD Sharing
- Will not share