Comparison of Sealing Ability of MTA and Biodentine for Repairing of Furcal Perforation in Primary Molars

NCT05006755 | Unknown

• 1 other identifier: 1692
• Study Type: interventional
• Target: 42
• Locations: 0 countries
• Sites: N/A

Brief Summary

• Preservation of the primary teeth is a mandatory issue for maintaining the integrity of the normal dentition and functioning till the eruption of the successors.
• furcal perforations may occur due to iatrogenic and non-iatrogenic causes.
• Despite the high successful outcomes in perforation repair with MTA, there are some issues which prevent the clinicians from using it for many cases such as its very long setting time and its difficult manipulation.
• Biodentin could be used as an alternative to MTA in reparative treatment procedures due to its ability to provide a hermetic seal and durable restoration and thus an optimal sealing is expected.
• The importance of the trial lies in testing the sealing ability of Biodentine using scanning electron microscope. Biodentine has short setting time and is easier in manipulation than MTA which are major needs when dealing with pediatric patients to be able to give best results in short time.

Conditions

Tooth Injuries

Outcome Measures

Primary Outcomes (1)

• sealing ability

  * measured by scanning electron microscope * Unit of measurement : µm

  24 hours

Study Arms (2)

control group

EXPERIMENTAL

the group of primary molar teeth that will be treated in furcal perforation with Mineral Trioxide Aggregate

Combination Product: Mineral Trioxide Aggregate

experimental group

EXPERIMENTAL

the group of primary molar teeth that will be treated in furcal perforation with Biodentine

Combination Product: Biodentine

Interventions

Mineral Trioxide Aggregate COMBINATION_PRODUCT

Mineral Trioxide Aggregate stimulates cementoblasts to produce matrix for cementum formation and is biocompatible with the periradicular tissues thus shows a superior sealing ability when used in perforation repair

Also known as: MTA

control group

Biodentine COMBINATION_PRODUCT

Biodentine has a good sealing ability, high compressive strengths, short setting time, biocompatibility, bioactivity and biomineralization properties that make it available to be used in endodontic repair procedures

experimental group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Freshly extracted discarded primary molars
• Primary molars with intact furcation ( no caries, no perforation, no resorption )
• Physiologic root resorption not more than two-third of root length

You may not qualify if:

• Exfoliated primary molars
• Primary molars with internal resorption
• Primary molars with extensive tooth decay of the crown
• Primary molars with discoloration
• Cracked tooth

Sponsors & Collaborators

• Amany hasanean Abd El sadek: lead

MeSH Terms

Conditions

Tooth Injuries

Interventions

mineral trioxide aggregate; Pemetrexed; tricalcium silicate

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Guanine; Hypoxanthines; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Glutamates; Amino Acids, Acidic; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Dicarboxylic

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: student

Study Record Dates

• First Submitted: August 9, 2021
• First Posted: August 16, 2021
• Study Start: September 10, 2021
• Primary Completion: September 10, 2021
• Study Completion: September 10, 2022
• Last Updated: August 25, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share