The Effect of the Nature And Frequency of a Stimulation on the Amplitude of the Temporal Summation of Pain

NCT05006066 | Unknown

• 1 other identifier: 2022-4323
• Study Type: observational
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

Temporal summation is a mechanism that enhances pain perception. It is a natural mechanism present in most individuals. Generally, temporal summation is measured by the application of a moderately painful stimulation for several seconds.However, there is still no official recommendation in the literature. There is therefore a great disparity in the protocols. Some studies apply thermal stimulation (heating the skin) while others apply mechanical stimulation (applying pressure). Another point of contention is that some studies apply continuous stimulation for 2 minutes while others apply a series of several small stimulation of 1 second). Between these studies, the amplitude of temporal summation varies according to the stimulation performed. Note also that the study population is also very different between studies. In these conditions, it remains difficult to know the impact of the nature of the stimulation on the measured amplitude of the temporal summation.

Conditions

Healthy

Keywords

Temporal Summation; Mechanical Stimulation; Heat Pain Stimulation; Thermode

Outcome Measures

Primary Outcomes (4)

• Temporal Summation of Pain - repetitive thermal stimulation

  Temporal Summation of pain referred to the change of pain perception during a painful stimulation. Temporal summation will be calculated by the difference in pain perception (on a 0-100 scale) and the beginning and at the end of each stimulation sequence. Temporal summation will be express as a percentage of increased.

  During stimulation

• Temporal Summation of Pain - continuous thermal stimulation

  Temporal Summation of pain referred to the change of pain perception during a painful stimulation. Temporal summation will be calculated by the difference in pain perception (on a 0-100 scale) and the beginning and at the end of each stimulation sequence. Temporal summation will be express as a percentage of increased.

  During stimulation

• Temporal Summation of Pain - continuous mechanical stimulation

  Temporal Summation of pain referred to the change of pain perception during a painful stimulation. Temporal summation will be calculated by the difference in pain perception (on a 0-100 scale) and the beginning and at the end of each stimulation sequence. Temporal summation will be express as a percentage of increased.

  During stimulation

• Temporal Summation of Pain - repetitive mechanical stimulation

  Temporal Summation of pain referred to the change of pain perception during a painful stimulation. Temporal summation will be calculated by the difference in pain perception (on a 0-100 scale) and the beginning and at the end of each stimulation sequence. Temporal summation will be express as a percentage of increased.

  During stimulation

Study Arms (1)

Healthy volunteers - Pain-Free

Each participant will be stimulated with 4 temporal summation stimulation conditions: * continuous thermal (1 stimulation of two minutes) * repetitive thermal (30 stimulations of 1 second) * continuous mechanical (1 stimulation of two minutes) * repetitive mechanical (30 stimulation of 1 second)

Other: Temporal Summation

Interventions

Temporal Summation OTHER

4 type of stimulations applied on the right arm

Healthy volunteers - Pain-Free

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

For this project, healthy males and females (1:1 ratio) between the ages of 18 and 30 will represent our target population

You may qualify if:

• Subjects aged 18 to 30 years, able to consent (understand English or French)
• No chronic pain
• No primary sensory disorders

You may not qualify if:

• Presence of upper extremity injuries
• Absence of anxiety symptoms (HADs Score \< 6) (Appendix 1)
• Presence of cardiovascular disease / neurocognitive disorders / mental illness
• Pregnant or postpartum women less than one year old

Sponsors & Collaborators

• Université de Sherbrooke: lead
• Canadian Institutes of Health Research (CIHR): collaborator

Study Sites (1)

Université de Sherbrooke

Sherbrooke, Quebec, JH1 5N4, Canada

RECRUITING

MeSH Terms

Interventions

Postsynaptic Potential Summation

Intervention Hierarchy (Ancestors)

Synaptic Transmission; Signal Transduction; Biochemical Phenomena; Chemical Phenomena; Synaptic Potentials; Membrane Potentials; Cell Physiological Phenomena; Electrophysiological Phenomena; Physiological Phenomena; Nervous System Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Guillaume Léonard, Ph.D

  Université de Sherbrooke

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Matthieu Vincenot, MS.c

CONTACT

819-780-2220; Matthieu.Vincenot@USherbrooke.ca

Guillaume Léonard, Ph.D

CONTACT

819-821-8000; Guillaume.Leonard2@USherbrook.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 21, 2021
• First Posted: August 16, 2021
• Study Start: July 12, 2021
• Primary Completion: August 30, 2022
• Study Completion: August 30, 2022
• Last Updated: May 19, 2022

Record last verified: 2022-05

Locations

CA (1)