Yorkshire Kidney Screening Trial

NCT05005195 | Unknown DMC

• 1 other identifier: 290336
• Study Type: interventional
• Target: 5,850
• Locations: 1 country
• Sites: 1

Brief Summary

Kidney cancer is the 8th most common cancer in Yorkshire. It has a poor survival rate, with only 6 out of 10 patients diagnosed with kidney cancer still alive after 5 years. This is partly because many people with kidney cancer don't have any symptoms. In some of these people, kidney cancer is only found by chance during investigations for other reasons. In others, it is often not diagnosed until the disease has passed the point at which we can easily cure it. Screening for kidney cancer has the potential to pick up these cancers earlier and increase the number of people who can be cured. The Yorkshire Lung Screening Trial offers people aged 55-80 with a history of smoking a CT scan as part of a lung health check. This group of people is also at increased risk of developing kidney cancer. Our new study, the Yorkshire Kidney Screening Trial, will piggyback on this trial to offer an extra CT scan for kidney cancer. The extra scan will take 10 seconds. By the end of the study we will understand whether it is workable to roll this out more widely and whether people take up this extra scan.

Conditions

Renal Cell Carcinoma

Keywords

Screening; Feasibility study

Outcome Measures

Primary Outcomes (4)

• The proportion of individuals who take up the offer of an abdominal CT scan

  The proportion of individuals attending the T2 round of YLST who take up the offer of an abdominal CT scan

  At the end of the 18 month recruitment period

• The acceptability of the combined lung and RCC screening approach to participants

  The acceptability to participants of combined lung and RCC screening by non-contrast CT scanning - ascertained by interviews

  On completion of the patient interview analysis - by the end of the 18 month recruitment period

• The acceptability of the combined lung and RCC screening approach to healthcare professionals

  The acceptability to healthcare professionals involved in the screening of combining RCC screening by non-contrast CT scanning with lung cancer screening - ascertained by interviews

  On completion of the health care professional interview analysis - by the end of the 18 month recruitment period

• The additional time required for the combined screening approach

  The additional time required for the combined screening approach, including the time to provide information, consent participants, and perform the lengthier CT scan, the time needed by radiologists for reporting the CT scans, and the additional time to review abdominal CT findings

  On completion of the study process observation analysis - by the end of the 18 month recruitment period

Secondary Outcomes (5)

• Estimate of the prevalence of RCC

  At the end of the 18 month recruitment period

• The stage distribution of all RCCs identified, reported as cancer findings with TNM

  At the end of the 18 month recruitment period

• The proportion of participants found to have incidental renal findings

  At the end of the 18 month recruitment period

• The proportion of participants with non-renal findings

  At the end of the 18 month recruitment period

• Estimation of the incidence of RCC

  At the end of the 18 month recruitment period

Study Arms (1)

Abdominal CT Scan

OTHER

A policy of invitation to a targeted community-based non-contrast CT screening of the abdomen in those at risk of kidney cancer.

Radiation: Low dose abdominal computed tomography scan

Interventions

Low dose abdominal computed tomography scan RADIATION

A policy of invitation to a targeted community-based non-contrast CT screening of the abdomen in those at risk of kidney cancer

Abdominal CT Scan

Eligibility Criteria

• Age: 55 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• High risk for lung cancer as defined by one of the three criteria:
• pack year history of smoking and current smoker or quit within the last 15 years (USPSTF criteria).
• Lung cancer risk of ≥1.51% over 6 years as calculated by the PLCOM2012 score.
• Lung cancer risk of ≥5% over 5 years as calculated by the LLPv2. score.

You may not qualify if:

• Have undergone CT Thorax within the previous 6 months
• Unable to provide informed consent to study
• Unable to have a chest or abdominal non-contrast CT scan
• Previous diagnosis of kidney cancer
• Have undergone abdominal CT scan in previous 6 months

Sponsors & Collaborators

• University of Leeds: lead
• University of Cambridge: collaborator
• Yorkshire Cancer Research: collaborator
• The Leeds Teaching Hospitals NHS Trust: collaborator

Study Sites (1)

Leads Teaching Hospitals Trust

Leeds, Yorkshire, LS1 3EX, United Kingdom

Location

Related Publications (2)

• Thomas C, Heathcote L, Sun Y, Callister MEJ, Kitt J, Rossi SH, Shinkins B, Usher-Smith JA, Whyte S, Stewart GD; YKST Study Group. Cost-effectiveness of one-off upper abdominal CT screening as an add-on to lung cancer screening in England. Br J Cancer. 2025 Aug;133(2):239-247. doi: 10.1038/s41416-025-03043-z. Epub 2025 May 14.

  PMID: 40369122 DERIVED

• Usher-Smith JA, Godoy A, Burge SW, Burbidge S, Cartledge J, Crosbie PAJ, Eckert C, Farquhar F, Hammond D, Hancock N, Iball GR, Kimuli M, Masson G, Neal RD, Rogerson S, Rossi SH, Sala E, Smith A, Sharp SJ, Simmonds I, Wallace T, Ward M, Callister MEJ, Stewart GD. The Yorkshire Kidney Screening Trial (YKST): protocol for a feasibility study of adding non-contrast abdominal CT scanning to screen for kidney cancer and other abdominal pathology within a trial of community-based CT screening for lung cancer. BMJ Open. 2022 Sep 20;12(9):e063018. doi: 10.1136/bmjopen-2022-063018.

  PMID: 36127097 DERIVED

Related Links

• YKST twitter account

MeSH Terms

Conditions

Carcinoma, Renal Cell

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Kidney Neoplasms; Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases

Study Officials

• Grant D Stewart

  University of Cambridge

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: There is no randomisation in this study.
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: A non-randomised feasibility study of adding non-contrast CT scanning of the abdomen to the CT chest undertaken in the T2 round of YLST. YLST is a two-arm, (1:1) implementation study using a single-consent Zelen's randomised controlled design. Participants have already been randomised to intervention (invitation to an initial telephone-based riskassessment and then, if eligible, for a Lung Health Check (LHC) which is carried out on a mobile van and incorporates LDCT scanning for lung cancer) or usual care (no invitation).

Study Record Dates

• First Submitted: August 4, 2021
• First Posted: August 13, 2021
• Study Start: May 10, 2021
• Primary Completion: April 30, 2023
• Study Completion: April 30, 2023
• Last Updated: November 2, 2022

Record last verified: 2022-11

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)