The Effect of Beetroot Juice on Plasma Trimethylamine N-oxide Concentration
BRJ_TMAO
Analysis of Electromyography Activation Trunk Muscles and the Effect of Beetroot Juice Intake on the Results in Strength Exercises: Lateral Medicine Ball Throw and Sled Pushing
1 other identifier
interventional
20
1 country
1
Brief Summary
The primary aim of the current study is to determine the effect of beetroot juice consumption on plasma trimethylamine N-oxide concentration. A secondary aims: exploring the effect of circulating trimethylamine N-oxide modification on plasma total antioxidant status, and measurement of changes in the skin nicotinamide-adenine dinucleotide reduced form (NADH) content during transient ischemia and reperfusion.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable hypertension
Started Sep 2021
Typical duration for not_applicable hypertension
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 5, 2021
CompletedFirst Posted
Study publicly available on registry
August 13, 2021
CompletedStudy Start
First participant enrolled
September 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 15, 2023
CompletedNovember 15, 2023
September 1, 2023
2.2 years
August 5, 2021
November 14, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
The effect of beetroot juice consumption on plasma trimethylamine N-oxide concentration
Determination of plasma trimethylamine N-oxide concentration following the beetroot juice consumption using ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) method.
4 hours
Secondary Outcomes (1)
The effect of circulating trimethylamine N-oxide modification on plasma total antioxidant status
4 hours
Study Arms (2)
beetroot juice
EXPERIMENTALsingle intake of beetroot juice containing 800mg nitrates
nitrates
ACTIVE COMPARATORsingle intake of 800mg nitrates (NaNO3)
Interventions
single intake of beetroot juice containing 800mg nitrates
Eligibility Criteria
You may qualify if:
- healthy volunteers
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Akademia Wychowania Fizycznego
Poznan, 61-871, Poland
Related Publications (1)
Jurga J, Samborowska E, Zielinski J, Olek RA. Effects of Acute Beetroot Juice and Sodium Nitrate on Selected Blood Metabolites and Response to Transient Ischemia: A Crossover Randomized Clinical Trial. J Nutr. 2024 Feb;154(2):491-497. doi: 10.1016/j.tjnut.2023.12.018. Epub 2023 Dec 16.
PMID: 38110180DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Robert A Olek, PhD
Poznan University of Physical Education
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
August 5, 2021
First Posted
August 13, 2021
Study Start
September 1, 2021
Primary Completion
December 1, 2023
Study Completion
December 15, 2023
Last Updated
November 15, 2023
Record last verified: 2023-09