NCT05001477

Brief Summary

This patient registry will capture data from patients who have been or who are undergoing the transurethral ultrasound ablation (TULSA) procedure as part of their routine clinical care. The registry will shed light on real-world outcomes of safety and efficacy of the procedure and understand how a patient's quality of life is affected throughout their follow-up and lifetime.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,000

participants targeted

Target at P75+ for all trials

Timeline
430mo left

Started Oct 2021

Longer than P75 for all trials

Geographic Reach
1 country

5 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress12%
Oct 2021Oct 2061

First Submitted

Initial submission to the registry

May 13, 2021

Completed
3 months until next milestone

First Posted

Study publicly available on registry

August 12, 2021

Completed
3 months until next milestone

Study Start

First participant enrolled

October 27, 2021

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2026

Expected
35 years until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2061

Last Updated

November 6, 2024

Status Verified

November 1, 2023

Enrollment Period

4.9 years

First QC Date

May 13, 2021

Last Update Submit

November 5, 2024

Conditions

Keywords

Prostate ablationhigh intensity transurethral ultrasound ablationMRI-guidedminimally invasivereal-time temperature feedback controlprostate cancerBPHTULSA

Outcome Measures

Primary Outcomes (2)

  • Rate of complications

    estimating the rate of complications (Clavien-Dindo grades III - IV) attributable to the TULSA Procedure

    5 years

  • Freedom from treatment failure

    Estimating the proportion of patients who are free from primary treatment failure after the TULSA Procedure.

    5 years

Secondary Outcomes (18)

  • Complications Data

    Lifelong up to 99 years

  • Biopsy Data

    Between 6 and 18 months post TULSA Procedure

  • Prostate Volume Reduction on MRI

    Between 6 and 18 months post TULSA Procedure

  • Suspicious cancerous lesions on MRI

    Between 6 and 18 months post TULSA Procedure

  • PSA Data

    Lifelong up to 99 years

  • +13 more secondary outcomes

Interventions

Transurethral ultrasound ablation procedure

Eligibility Criteria

Age18 Years+
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

This study will include as many eligible subjects as willing to participate who have undergone or will be undergoing the TULSA Procedure.

You may qualify if:

  • Male
  • \>18 years old
  • Candidate for TULSA-PRO treatment
  • willing and able to sign the Informed Consent form

You may not qualify if:

  • None.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (5)

RadNet's Liberty Pacific West Hills Facility

West Hills, California, 91307, United States

RECRUITING

Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States

RECRUITING

Wellspan Health

York, Pennsylvania, 17403, United States

RECRUITING

University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States

RECRUITING

Urology Place

San Antonio, Texas, 78240, United States

RECRUITING

MeSH Terms

Conditions

Prostatic NeoplasmsProstatic Hyperplasia

Condition Hierarchy (Ancestors)

Genital Neoplasms, MaleUrogenital NeoplasmsNeoplasms by SiteNeoplasmsGenital Diseases, MaleGenital DiseasesUrogenital DiseasesProstatic DiseasesMale Urogenital Diseases

Central Study Contacts

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Target Duration
40 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 13, 2021

First Posted

August 12, 2021

Study Start

October 27, 2021

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

October 1, 2061

Last Updated

November 6, 2024

Record last verified: 2023-11

Data Sharing

IPD Sharing
Will not share

Locations