Relationship Between The Quadriceps Muscle Stiffness And Patellar Alignment For Healthy People

NCT04982679 | Completed

• 1 other identifier: 20038261r
• Study Type: observational
• Target: 59
• Locations: 1 country
• Sites: 1

Brief Summary

Patellofemoral pain is a common disease, and it often couples with patellar malalignment. Previously, imbalance of the different quadriceps muscle heads was believed to be a causative factor of patellar malignment. However, findings from electromyography studies on quadriceps activities and patellar alignment in the last two decades were inconsistent. In order to better understand the relationship between quadriceps muscle imbalance and patellar malalignment, shear wave elastography (SWE), which can measure the passive and active muscle stiffness, may shed some new lights to this area. This study aims to examine whether the quadriceps muscle stiffness can predict the patellar position. The healthy young adult will be recruited in this study. Active and passive quadriceps muscle stiffness will be measured with the SWE in different conditions and the result will be correlated with the patellar position measured with magnetic resonance imaging (MRI). Also, electromyography (EMG) activity will be measured during the active stiffness measurement so as to establish the level of agreement between the EMG and SWE data. Linear regression will be used to calculate the relationship between different factors. The total number of subjects needed will be 55 by setting an effect size of 0.15 with two predictors, 80% power, and α at 0.05 in the linear regression. This project will be conducted at PolyU campus and an MRI clinic in Hong Kong. Hopefully, it could be started in July 2021 and will last for 1 year.

Conditions

Patellofemoral Maltracking

Keywords

muscle stiffness; patellofemoral alignment

Outcome Measures

Primary Outcomes (2)

• Patellofemoral Joint Alignment measured by MRI scanning

  Patellar displacement, patellar Alta/Baja and patellar tilt angle

  Within 1 hour

• Muscle stiffness measured by ultragraph using shear wave elastography

  Raw data of vastus lateralis, rectus femoris and vastus medialis obliquus shear modulus

  Within 1 hour

Secondary Outcomes (2)

• Muscle activity measured by electromyography

  Within 1 hour

• Muscle strength

  Within 0.5 hour

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Healthy subject without patellofemoral joint problem

You may qualify if:

• Healthy and in the range between 18 and 45 years.

You may not qualify if:

• Knee pain in the last 3 months;
• Previous history of knee surgery;
• People with contraindications to having MRI scanning.

Sponsors & Collaborators

• The Hong Kong Polytechnic University: lead

Study Sites (1)

Hong Kong Polytechnic University

Hung Hom, 000000, Hong Kong

Location

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 20, 2021
• First Posted: July 29, 2021
• Study Start: November 26, 2021
• Primary Completion: February 9, 2022
• Study Completion: February 9, 2022
• Last Updated: March 16, 2022

Record last verified: 2021-07

Locations

HK (1)