Research on the Application and Mechanism of New Biological Probes in Biomedicine

NCT04977739 | Completed

• 1 other identifier: NFEC-2021-007
• Study Type: observational
• Target: 737
• Locations: 1 country
• Sites: 1

Brief Summary

Fluorescence is one of the most commonly used research and detection techniques in the field of biomedical science. The characteristics of fluorescent probe directly affect the performance and application of fluorescence analysis and imaging. Aggregation-Caused Quenching has limited the application of traditional fluorescent probes to some extent. This project intends to systematically evaluate the detection efficiency of new methods through the detection of biomarkers in clinical samples and the comparison with the detection methods of traditional biomarkers, so as to provide theoretical and experimental basis for the establishment of fast and simple biomarker detection technologies with new biological probes.

Conditions

Tumors; Cardiovascular Diseases; Respiratory System Diseases; Digestive System Diseases; Endocrine System Diseases; Metabolic Diseases; Immune System Diseases; Urinary System Diseases; Nervous System Diseases; Blood Diseases; Infectious Diseases

Outcome Measures

Primary Outcomes (1)

• signal intensity of the probes

  one day

Study Arms (2)

those with a condition

Diagnostic Test: No intervention

those without a condition

Diagnostic Test: No intervention

Interventions

No intervention DIAGNOSTIC_TEST

No intervention

those with a condition; those without a condition

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

NanFang Hospital samples

You may qualify if:

• Sign the informed consent form voluntarily.
• Age 18-70 years old.
• High expression (positive) group: The results of multiple laboratory tests indicate that the marker is higher than the normal range.
• Low expression (negative) healthy volunteer group: those with no underlying diseases and no abnormalities in the physical examination.
• Have routine examination to check the remaining body fluid samples, and the body fluid samples are not contaminated.

You may not qualify if:

• Accompanied by other inflammations.
• The data of the subject is not complete, or the collection of cases is incomplete due to other reasons.
• The researcher judged that it was not suitable to participate in this research.

Sponsors & Collaborators

• Nanfang Hospital, Southern Medical University: lead

Study Sites (1)

Nanfang Hospital

Guangzhou, Guangdong, 510515, China

Location

MeSH Terms

Conditions

Neoplasms; Cardiovascular Diseases; Respiratory Tract Diseases; Digestive System Diseases; Endocrine System Diseases; Metabolic Diseases; Immune System Diseases; Urologic Diseases; Nervous System Diseases; Hematologic Diseases; Communicable Diseases

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Hemic and Lymphatic Diseases; Infections; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Bo Situ

  Nanfang Hospital, Southern Medical University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 14, 2021
• First Posted: July 27, 2021
• Study Start: August 3, 2021
• Primary Completion: July 15, 2022
• Study Completion: July 25, 2022
• Last Updated: August 22, 2022

Record last verified: 2021-06

Locations

CN (1)