Metabolic Activation of Brain Areas With Emotional Stimuli Compared With Score in Psychological Test

NCT04974437 | Completed DMC

• 1 other identifier: 2
• Study Type: observational
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

Quantitative assessment of the activation of brain areas by functional magnetic resonance imaging (fRMI) in the face of positive and negative emotional stimuli using audiovisual materials validated for the local population and its correlation with degrees of emotional disorder based on a score obtained by a validated questionnaire for the local population, in 16 volunteers from the city of La Rioja in Argentina.

Conditions

Emotional Disorder

Keywords

fMRI; Emotion; Cerebral blood volume

Outcome Measures

Primary Outcomes (1)

• Differences in fMRI brain activation response in specific brain regions in response to positive and negative emotional stimuli

  A score will be assigned to each participant according to the results obtained in a validated questionnaire to categorize emotional disorder with 37 questions, each of them with a score of 0, 1 or 2 according to the answer, to give a score to each participant that will be on the scale from 0 to 74. The stimuli consist of the projection of audiovisual material validated to generate positive or negative emotions. The activations are quantified in a 1.5 Tesla resonator and the units of measurement for each region of interest will be cm3 of activated tissue and Z-value of fMRI activation. Once the informed consent is signed, the participant is asked to answer the questionnaire to categorize the emotional score. After this survey, the fMRI is acquired, measuring the activation by areas from the beginning of the audiovisual stimuli until their completion. The time for the fMRI acquisition session for each participant in this cross-sectional study is estimated 20-minute .

  Cross sectional adquistion of data with fMRI in a 20 minutes session after answering a questionnaire.

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Volunteer participants from the population of the city of La Rioja in Argentina, over 21 years of age.

You may qualify if:

• \- Must be able to understand the instructions and collaborate during the data adquisition.

You may not qualify if:

• Any contraindication to enter an MRI (for example, a pacemaker)
• Claustrophobia.

Sponsors & Collaborators

• Instituto del Corazon, Argentina: lead

Study Sites (1)

Incor

La Rioja, 5300, Argentina

Location

Related Publications (9)

• Michelini, Y. Características de la experiencia emocional inducida mediante fragmentos de películas en una muestra de jóvenes argentinos. Interdisciplinaria, 2015, 32, 2, 367-382.

  BACKGROUND

• Muñoz Rodriguez M, Korzeniowski C. Validación del cuestionario epidemiológico en sintomatología mental -CESIM- en población Argentina. Revista de Salud Pública, (XXIII) 2:8-24 Junio 2019

  BACKGROUND

• Gu S, Wang F, Cao C, Wu E, Tang YY, Huang JH. An Integrative Way for Studying Neural Basis of Basic Emotions With fMRI. Front Neurosci. 2019 Jun 19;13:628. doi: 10.3389/fnins.2019.00628. eCollection 2019.

  PMID: 31275107 BACKGROUND

• Kragel PA, Knodt AR, Hariri AR, LaBar KS. Decoding Spontaneous Emotional States in the Human Brain. PLoS Biol. 2016 Sep 14;14(9):e2000106. doi: 10.1371/journal.pbio.2000106. eCollection 2016 Sep.

  PMID: 27627738 BACKGROUND

• Kragel PA, LaBar KS. Multivariate neural biomarkers of emotional states are categorically distinct. Soc Cogn Affect Neurosci. 2015 Nov;10(11):1437-48. doi: 10.1093/scan/nsv032. Epub 2015 Mar 25.

  PMID: 25813790 BACKGROUND

• Kassam KS, Markey AR, Cherkassky VL, Loewenstein G, Just MA. Identifying Emotions on the Basis of Neural Activation. PLoS One. 2013 Jun 19;8(6):e66032. doi: 10.1371/journal.pone.0066032. Print 2013.

  PMID: 23840392 BACKGROUND

• Gur RE, Gur RC. Functional magnetic resonance imaging in schizophrenia. Dialogues Clin Neurosci. 2010;12(3):333-43. doi: 10.31887/DCNS.2010.12.3/rgur.

  PMID: 20954429 BACKGROUND

• Posner J, Russell JA, Gerber A, Gorman D, Colibazzi T, Yu S, Wang Z, Kangarlu A, Zhu H, Peterson BS. The neurophysiological bases of emotion: An fMRI study of the affective circumplex using emotion-denoting words. Hum Brain Mapp. 2009 Mar;30(3):883-95. doi: 10.1002/hbm.20553.

  PMID: 18344175 BACKGROUND

• Rios-Lago M. [Functional magnetic resonance and neuropsychology: basic concepts]. Radiologia. 2008 Sep-Oct;50(5):351-65; quizz 365. doi: 10.1016/s0033-8338(08)76050-8. Spanish.

  PMID: 19055911 BACKGROUND

Study Officials

• Ruben F Novoa, MD

  InCor Heart Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Magnetic Resonance Imaging, Principal Investigator

Study Record Dates

• First Submitted: June 23, 2021
• First Posted: July 23, 2021
• Study Start: August 1, 2021
• Primary Completion: October 25, 2021
• Study Completion: November 25, 2021
• Last Updated: November 29, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: Immediately following publication and ending 36 months following article publication.
• Access Criteria: Proposals should be directed to rubennnovoa@gmail.com. To gain access, data requestors will need to sign a data access agreement.

Locations

AR (1)