The Effect of Phosphatidylserine on Time Trial Performance in Trained Male Cyclists

NCT04967404 | Unknown

• 1 other identifier: StMarysUC
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

Phosphatidylserine is a phospholipid found in high concentrations in the brain and nervous tissues along with naturally occurring in many foods. It has been extensively studied for its effects on improving cognitive function, learning, memory and alleviating stress. However, more recently it has been proposed that phosphatidylserine could improve exercise capacity. The mechanisms of proposed action are difficult to distinguish because of the limited research and therefore the purpose of this study is to identify the proposed mechanism of action of phosphatidylserine supplementation and to establish whether these mechanisms will have an effect on time trial performance in trained male cyclists.

Conditions

The Focus of the Study is to Investigate the Effects of Phosphatidylserine Supplementation on Exercise Physiology and Cycling Time-trial Performance

Outcome Measures

Primary Outcomes (1)

• 30 minute cycling time-trial power output on an electromagnetically-braked cycle ergometer

  Mean power output

  From baseline to 11 days post supplementation

Secondary Outcomes (8)

• Oxygen consumption at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

  From baseline to 11 days post supplementation

• Respiratory exchange ratio at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

  From baseline to 11 days post supplementation

• Breathing frequency at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

  From baseline to 11 days post supplementation

• Minute ventilation at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

  From baseline to 11 days post supplementation

• Blood lactate concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

  From baseline to 11 days post supplementation

Study Arms (2)

Phosphatidylserine, 800 mg per day, 10 days

EXPERIMENTAL

Dietary Supplement: Phosphatidylserine

Maltodextrin, 800 mg per day, 10 days

PLACEBO COMPARATOR

Dietary Supplement: Phosphatidylserine

Interventions

Phosphatidylserine DIETARY_SUPPLEMENT

800 mg per day for 10 days

Maltodextrin, 800 mg per day, 10 days; Phosphatidylserine, 800 mg per day, 10 days

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: All participants must be trained male cyclists
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Cyclists
• Maximum oxygen uptake of at least 55 mL/kg/min

Sponsors & Collaborators

• Mark Glaister: lead

MeSH Terms

Interventions

Phosphatidylserines

Intervention Hierarchy (Ancestors)

Glycerophospholipids; Phosphatidic Acids; Glycerophosphates; Phospholipids; Membrane Lipids; Lipids

Central Study Contacts

Mark Glaister, PhD

CONTACT

02082404012; mark.glaister@stmarys.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: The experiment will follow a double-blind design where all participants and investigators will be blinded to the treatments given.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants matched on cycling time-trial performance and then randomly assigned to treatment or placebo groups

Study Record Dates

• First Submitted: June 11, 2021
• First Posted: July 19, 2021
• Study Start: July 15, 2021
• Primary Completion: September 22, 2021
• Study Completion: September 22, 2021
• Last Updated: July 19, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share