Role of Clinical Pharmacists in Epilepsy Management

NCT04967326 | Completed Phase 4

• 1 other identifier: 23-2015/CN-HĐĐĐ
• Study Type: interventional
• Target: 141
• Locations: 0 countries
• Sites: N/A

Brief Summary

Clinical pharmacists have an important role in inter-professional healthcare collaboration for epilepsy management. However, the pharmacy practices of managing epilepsy are still limited in Vietnam, deterring pharmacists from routine adjustments of antiepileptic drugs, which could decrease the patients' quality of life. This study aimed to assess the effectiveness of pharmacist interventions in epilepsy treatment at a Vietnamese general hospital.

Conditions

Epilepsy

Keywords

epilepsy; role of pharmacist; adverse drug reaction; antiepileptic drug; Vietnam

Outcome Measures

Primary Outcomes (1)

• Number of patients with two seizures or less

  Patients with two seizures or less in a year were categorized as having good control, whereas those who had more were considered to have poor control.

  One year from the start of the study

Secondary Outcomes (1)

• Number of patients who maintained an optimized concentration of antiepileptic drugs

  One year from the start of the study

Study Arms (1)

Patients with epilepsy

EXPERIMENTAL

The therapies of patients with epilepsy were optimized using pharmacists' interventions, including medication consultation, dosage adjustment, medication switching/discontinuation, or combination therapy.

Drug: Optimizing therapy with antiepileptic drugs (carbamazepine, phenytoin, valproic acid)

Interventions

Optimizing therapy with antiepileptic drugs (carbamazepine, phenytoin, valproic acid) DRUG

Patients with epilepsy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• were prescribed a monotherapy or polytherapy of phenytoin, carbamazepine, or valproic acid.
• were treated for more than one month.

You may not qualify if:

• were pregnant or breastfeeding women.
• had a history of alcoholism.
• had liver or renal disease.
• were using drugs known to have an influence on cytochrome P450 enzymes.

Sponsors & Collaborators

• Gia Dinh People Hospital: lead

Related Publications (1)

• Pham HT, Tran MH, Nguyen NQ, Tan Vo V, Tran MH. Role of clinical pharmacists in epilepsy management at a general hospital in Vietnam: a before-and-after study. J Pharm Policy Pract. 2021 Dec 20;14(1):109. doi: 10.1186/s40545-021-00394-9.

  PMID: 34930487 DERIVED

MeSH Terms

Conditions

Epilepsy; Drug-Related Side Effects and Adverse Reactions

Interventions

Anticonvulsants; Carbamazepine; Phenytoin; Valproic Acid

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Chemically-Induced Disorders

Intervention Hierarchy (Ancestors)

Central Nervous System Agents; Therapeutic Uses; Pharmacologic Actions; Chemical Actions and Uses; Dibenzazepines; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Hydantoins; Imidazolidines; Imidazoles; Azoles; Heterocyclic Compounds, 1-Ring; Pentanoic Acids; Valerates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Fatty Acids, Volatile; Fatty Acids; Lipids

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical pharmacist

Study Record Dates

• First Submitted: July 8, 2021
• First Posted: July 19, 2021
• Study Start: January 1, 2016
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: August 2, 2021

Record last verified: 2021-07