Working IVF Patients' Quality of Life

NCT04966091 | Completed

• 1 other identifier: RECHMPL20_0426
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Infertility affects approximately 1 in 6 couples and may require the use of Medically Assisted Reproduction techniques. In France, there were more than 60,000 in vitro fertilization (IVF) attempts in 2016. The burden of the IVF process is even more significant for working women, causing significant absenteeism due to medical appointments but also to the psychological discomfort caused by the management. Unfortunately, there are no studies that specifically address the quality of life of working women undergoing IVF. The cohort project aims to measure quality of life using validated questionnaires (FertiQoL, STAI Anxiety Scale and BDI Depression Inventory) in active patients who are scheduled for a first IVF attempt. Quality of life will be measured before starting treatment and at embryo transfer and will be followed up at each embryo transfer for a maximum period of 18 months. The follow-up will end after the live birth of a child or at the end of the 18 months of follow-up. The investigators will also evaluate, by means of a specific questionnaire, the satisfaction with the interactions between professional and private life (management and consequences of absenteeism at work, consequences on professional evolution, anxious repercussions in the professional and private domains) in the active women undergoing IVF treatment.

Conditions

In Vitro Fertilization (IVF); Infertility

Keywords

Infertility; Assisted Reproductive Techniques; quality of life; work; personal and professional interactions; depression

Outcome Measures

Primary Outcomes (1)

• Evaluate the evolution of the quality of life of active patients during their IVF course.

  Assessed by the Fertility Quality Of Life (FertiQoL) questionnaire score at 18 months or end of follow-up, compared with the one obtained at inclusion. The score obtained from this questionnaire is not based on a scale. 2 first items measures physical health and satisfaction with the quality of life in terms of fertility. 24 other items assesses the impact of fertility problems in several domains: 6 in the emotional, 6 in mind-body, 6 in the relational, 6 in social. http://sites.cardiff.ac.uk/fertiqol/description/instrument-description/

  At baseline and through study completion, at 6 months or 12 months or 18 months

Secondary Outcomes (4)

• Look for predictive factors of impaired quality of life.

  At baseline and through study completion, at 6 months or 12 months or 18 months

• Assess work/life interactions and their relationship to quality of life.

  At baseline and through study completion, at 6 months or 12 months or 18 months

• Look for predictive factors of dropout.

  At baseline and through study completion, at 6 months or 12 months or 18 months

• To compare the characteristics of patients who achieve pregnancy versus those who fail (Quality of life, anxiety, depression...)

  At baseline and through study completion, at 6 months or 12 months or 18 months

Interventions

Completion of questionnaires OTHER

The quality of life questionnaire will be completed before starting the treatment and then during the embryo transfer and will be followed up at each embryo transfer over a maximum period of 18 months. We will also evaluate by means of a specific questionnaire the importance of work/life interactions management and consequences of absenteeism at work, consequences on professional evolution, anxious repercussions in the professional and private domains).

Eligibility Criteria

• Age: 18 Years - 42 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Active women, aged between 18 and 42, undergoing IVF at Montpellier University Hospital.

You may qualify if:

• Professionally active women aged 18 to 42 years
• Beginning in vitro fertilization treatment at the Montpellier University Hospital

You may not qualify if:

• Women who have already had an IVF attempt in the process of egg donation or pre-implantation diagnosis
• History of psychotic or dissociative disorder
• Not fluent in French
• Not affiliated to a social security system
• Protected by law or under curators/guardianship
• No record of non-objection to participate in the study

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

CHU de Montpellier

Montpellier, 34295, France

Location

MeSH Terms

Conditions

Infertility; Depression

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases; Behavioral Symptoms; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 7, 2021
• First Posted: July 19, 2021
• Study Start: September 13, 2021
• Primary Completion: March 8, 2024
• Study Completion: November 7, 2025
• Last Updated: November 28, 2025

Record last verified: 2025-11

Locations

FR (1)