A Prospective Descriptive Study of the Individualized Capnography of Both Lungs During One-lung Ventilation With Double-lumen Tube

NCT04962581 | Completed

• 1 other identifier: 2022-3697, 22100
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

A prospective descriptive study of the use of an individualized capnography to each lung in the context of one-lung ventilation achieved with a double-lumen tube. \- Pilot project and proof of concept Brief Summary:

• One study suggests a way to predict possible events of hypoxemia (Sat O2 \< 90%) during one lung ventilation (OLV) with the use of two individualized capnography devices on each lung during two-lung ventilation before inducing OLV.
• In addition, a recent presentation in the 2021 Thoracic Anesthesia Symposium suggested possible benefits of the use of a capnography device on the non-ventilated lung in the detection of air leaks around the bronchial cuff.
• The same presentation demonstrated the utility of EtCo2 measurement to determine the achievement of complete lung collapse. With these previous demonstrations, the use of an individualized capnography for each lung can potentially describe different steps during thoracic surgery. Therefore, a descriptive prospective study on patients that require thoracic surgery with use of a double lumen tube is proposed to verify the feasibility of dual capnography during OLV. The use of two different devices, randomized during our study, will also help to identify the impact of different air aspiration levels on our measures. Such results will allow to put forward prospective projects to help to optimize OLV during thoracic surgeries.

Conditions

Thoracic Surgery; Video-Assisted; Double-Lumen Tube; Capnography

Keywords

One lung ventilation; Lung collapse; Capnography; Double lumen tube; DLT; Thoracic surgery; VATS; Video-assisted; Video assisted thoracoscopic surgery

Outcome Measures

Primary Outcomes (1)

• Characterize the expired CO2 during the different steps in one lung ventilation

  Characterize the expired CO2 during the different steps in one lung ventilation for both lungs: the isolated non-ventilated and the ventilated lung

  During Thoracic Surgery: From intubation to extubation

Secondary Outcomes (1)

• Performance and reliability of two capnography machines on the measure of the expired carbon dioxide

  During Thoracic Surgery: From intubation to extubation

Study Arms (2)

Group 1 : Covidien

This cohort will be monitored with the Covidien capnography, which will be connected to the isolated non-ventilated lung during the whole procedure.

Group 2: General Électrique

This cohort will be monitored with the General Electrique capnography, which will be connected to the isolated non-ventilated lung during the whole procedure.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The Study population is all patients that require one-lung ventilation thoracic surgery with use of double-lumen tubes.

You may qualify if:

• Use of double-lumen tubes for isolation of the lung
• Elective unilateral lung resection (anatomical segmentectomy, lobectomy or pneumonectomy) for lung cancer

You may not qualify if:

• Use of bronchial blockers
• IMC above 35

Sponsors & Collaborators

• Laval University: lead

Study Sites (1)

Institut de cardiologie et de pneumologie de Québec - Université Laval

Québec, Quebec, G1V 4G5, Canada

Location

Related Publications (2)

• Kiwakyou L. BJ. Free and Simple Confirmation of Lung Isolation adequacy. [Thoracic Anesthesia Symposium 2021, Poster Presentation #30]. In press 2021

  BACKGROUND

• Yamamoto Y, Watanabe S, Kano T. Gradient of bronchial end-tidal CO2 during two-lung ventilation in lateral decubitus position is predictive of oxygenation disorder during subsequent one-lung ventilation. J Anesth. 2009;23(2):192-7. doi: 10.1007/s00540-008-0737-9. Epub 2009 May 15.

  PMID: 19444556 BACKGROUND

MeSH Terms

Conditions

Pulmonary Atelectasis

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Officials

• Catherine Fortier

  Laval University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiologist, Principal Investigator, Clinical Professor

Study Record Dates

• First Submitted: July 5, 2021
• First Posted: July 15, 2021
• Study Start: July 4, 2021
• Primary Completion: September 1, 2021
• Study Completion: December 30, 2021
• Last Updated: August 22, 2022

Record last verified: 2022-08

Locations

CA (1)