The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease

NCT04959357 | Completed DMC

• 1 other identifier: 048-01
• Study Type: observational
• Target: 242
• Locations: 1 country
• Sites: 1

Brief Summary

The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to investigate the effect of different types of ischemic heart disease on the LV systolic function, and to explore the value of LS on the diagnosis of coronary microvascular dysfunction.

Conditions

Coronary Microvascular Dysfunction; Obstructive Coronary Heart Disease

Keywords

two-dimensional speckle tracking imaging; strain; coronary microvascular dysfunction

Outcome Measures

Primary Outcomes (1)

• global longitudinal strain

  global longitudinal strain of CMD group and obstructive CAD group

  15/3/2018-30/12/2018

Study Arms (3)

coronary microvascular dysfunction group

Diagnostic Test: Two dimensional speckle tracking imaging

obstructive coronary artery disease

Diagnostic Test: Two dimensional speckle tracking imaging

control group

Diagnostic Test: Two dimensional speckle tracking imaging

Interventions

Two dimensional speckle tracking imaging DIAGNOSTIC_TEST

lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging

control group; coronary microvascular dysfunction group; obstructive coronary artery disease

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A total of 242 patients were enrolled, including 102 males (42.1%) and 140 females (57.9%). Their ages ranged from 44 to 81 years, with an average age of (62.6 + 8.3) years.

You may qualify if:

• age from 18-85 years

You may not qualify if:

• patients with history of myocardial infarction or abnormal wall motion suggested by conventional echocardiography
• patients with acute heart failure, chronic heart failure or LVEF values less than 50%
• patients with congenital heart disease, severe valvular disease, severe bradycardia, high atrioventricular block and atrial fibrillation
• patients who did not store ultrasound images or whose ultrasound images were unclear
• patients who had incomplete clinical data

Sponsors & Collaborators

• Peking University Third Hospital: lead

Study Sites (1)

Department of Cardiology, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides

Beijing, Beijing Municipality, 100191, China

Location

MeSH Terms

Conditions

Sprains and Strains

Condition Hierarchy (Ancestors)

Wounds and Injuries

Study Officials

• Li Zhaoping, professor

  Peking University Third Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 27, 2021
• First Posted: July 13, 2021
• Study Start: March 15, 2018
• Primary Completion: October 30, 2018
• Study Completion: December 30, 2018
• Last Updated: July 13, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)