Understanding Visual Confusion Using Stereoscopic Displays

NCT04957745 | Completed Results

• 2 other identifiers: 2021P001757R01EY031777
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

In this research study we want to test how people understand a visual scene when the same image is presented to both the eyes, but portions of these images are altered in terms of contrast, depth or in some cases motion.

Conditions

Diplopia; Binocular Vision Suppression; Binocular; Fusion, With Defective Stereopsis; Monocular Diplopia

Keywords

Visual confusion; Rivalry; Head mounted display; Stereoscopic displays; Binocular vision

Outcome Measures

Primary Outcomes (1)

• Percentage of Total Viewing Time That Peripheral Target is Perceived

  (Total time the peripheral target in the visual confusion condition was visible) / (total viewing time (=1 min))

  Approximately 1-2 sessions to finish total 6 trials, up to 2 hours for each session, any time within the 4month study period

Study Arms (1)

Visual confusion

EXPERIMENTAL

Participants viewed peripheral targets in three different visual confusion conditions (three interventions): binocular visual confusion (unilateral opaque target), unilateral monocular visual confusion (unilateral see-through target), and bilateral monocular visual confusion (bilateral see-through target). Each intervention was presented twice in a randomized order, resulting in a total of six trials. During each trial, a peripheral target was presented in front of a forward-moving background for one minute. Participants were instructed to hold down the controller button while the target was visible and release it when a third or more of the target disappeared. After each trial, participants could take a brief break before the next trial in a different visual confusion condition was presented in a randomized order.

Behavioral: Binocular visual confusion (unilateral opaque); Behavioral: Unilateral monocular visual confusion (unilateral see-through); Behavioral: Bilateral monocular visual confusion (bilateral see-through)

Interventions

Binocular visual confusion (unilateral opaque) BEHAVIORAL

The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation. For the binocular visual confusion condition, the non-transparent (opaque) peripheral target will be displayed on only one eye (unilateral opaque display).

Visual confusion

Unilateral monocular visual confusion (unilateral see-through) BEHAVIORAL

The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation. For the unilateral monocular visual confusion condition, the half-transparent peripheral target will be displayed on only one eye (unilateral see-through display).

Visual confusion

Bilateral monocular visual confusion (bilateral see-through) BEHAVIORAL

The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation. For bilateral monocular visual confusion condition, the half-transparent peripheral target will be displayed on both eyes (bilateral see-through display).

Visual confusion

Eligibility Criteria

• Age: 14 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Better than 20/40 visual acuity in the worse eye
• No restrictions of the peripheral visual field: (at least 60 degrees vertically and 40 degrees horizontally)
• At least 14 years of age (no upper age limit)
• Able to give voluntary, informed consent
• Able to understand English
• Binocular vision parameters within normal limits (Stereopsis ≤ 100 arc sec on any stereo test)

You may not qualify if:

• Patients with any physical or mental disabilities, including cognitive dysfunction, balance problems, or other deficits that could impair their ability to respond to the stimuli presented in this study will be excluded
• Being unable to complete sessions lasting 2-3 hours

Sponsors & Collaborators

• Massachusetts Eye and Ear Infirmary: lead
• National Eye Institute (NEI): collaborator

Study Sites (1)

Schepens Eye Research Institute

Boston, Massachusetts, 02114, United States

Location

MeSH Terms

Conditions

Diplopia

Condition Hierarchy (Ancestors)

Vision Disorders; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Dr. Jaehyun Jung
• Organization: Schepens Eye Research Institute of Massachusetts Eye and Ear

jaehyun_jung@meei.harvard.edu

6179122525

Study Officials

• JaeHyun Jung

  Schepens Eye Research Institute

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: All participants in the group will see all three interventions (peripheral targets in three visual confusion conditions) in a randomized order. In this study design, each participant will serve as their own control, and the order of the interventions will be randomized to account for potential carryover or ordering effects. There will be no comparison or control group. The outcome will be compared through a within-subject analysis.

Study Record Dates

• First Submitted: June 28, 2021
• First Posted: July 12, 2021
• Study Start: November 9, 2021
• Primary Completion: July 27, 2022
• Study Completion: July 27, 2022
• Last Updated: July 10, 2023
• Results First Posted: July 10, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)