Evaluation of Left Ventricular Function and Therapeutic Effect of CPAP in Patients With OSAS by 3D STE

NCT04957004 | Completed

• 1 other identifier: M2017397
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The changes of left ventricular function in patients with sleep apnea were studied by three-dimensional speckle-tracking echocardiography to evaluate the changes of left ventricular function after CPAP treatment

Conditions

OSA; Left Ventricular Dysfunction

Keywords

OSA; CPAP; left ventricular dysfunction

Outcome Measures

Primary Outcomes (1)

• The changes of echocardiographic and serological indexes were observed by 3D speckled tracking during the 1-year follow-up

  The changes of echocardiographic indexs such as left ventricular three-dimensional strain and serological indexes including adiponectin.

  The follow-up period was 1 year

Study Arms (2)

OSA patients

Patients with OSA who have not been treated with CPAP

Device: CPAP

control group

health control except OSA by using sleep monitorin

Interventions

CPAP DEVICE

CPAP ventilator was worn at nigh

OSA patients

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with OSA who underwent sleep monitoring at the Sleep Medicine Center of Peking University Third Hospital were selected for the study.OSA met the diagnostic criteria of obstructive sleep apnea in the United States Classification of Sleep Diseases in 2014.Exclusion criteria from this study included previously diagnosed patients with heart failure,coronary artery disease,valvular disease,cardiomyopathy,arrhythmia,chronic obstructive/ restrictive pulmonary disease, thyroid dysfunction (including hypothyroidism or hyperthyroidism), already treated with CPAP, and poor image quality of echocardiography. Healthy subjects who underwent sleep monitoring to exclude OSA were selected as the control group during the same period.

You may qualify if:

• OSA met the diagnostic criteria of obstructive sleep apnea in the United States Classification of Sleep Diseases in 2014
• Between the ages of 18 and 80, regardless of gender
• Sign informed consent

You may not qualify if:

• previously diagnosed patients with heart failure,
• coronary artery disease,
• valvular disease,
• cardiomyopathy,
• arrhythmia,
• chronic obstructive/ restrictive pulmonary disease,
• thyroid dysfunction (including hypothyroidism or hyperthyroidism),
• already treated with CPAP,
• poor image quality of echocardiography.

Sponsors & Collaborators

• Peking University Third Hospital: lead

Study Sites (1)

Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China

Location

MeSH Terms

Conditions

Ventricular Dysfunction, Left

Condition Hierarchy (Ancestors)

Ventricular Dysfunction; Heart Diseases; Cardiovascular Diseases

Study Officials

• Yongzhen Zhang

  Peking University Third Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 29, 2021
• First Posted: July 9, 2021
• Study Start: July 22, 2018
• Primary Completion: December 22, 2019
• Study Completion: June 30, 2020
• Last Updated: July 9, 2021

Record last verified: 2021-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)