Association of Processing Speed Dysfunction and Brain Functional Abnormality in ECTS
1 other identifier
observational
68
1 country
1
Brief Summary
Epilepsy with centrotemporal spikes (ECTS) is the most common epilepsy syndrome in children. Language impairment has been widely investigated in patients with ECTS, but little is known about the cognitive dysfunction of processing speed and its neuroimaging mechanism.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jun 2019
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2021
CompletedFirst Submitted
Initial submission to the registry
July 6, 2021
CompletedFirst Posted
Study publicly available on registry
July 8, 2021
CompletedJuly 8, 2021
July 1, 2021
2 years
July 6, 2021
July 6, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Processing speed index
Processing speed index was measured according to Wechsler Intelligence Scale for Children
Through study completion, about 2 years
Standardized uptake value ratio
Standardized uptake value ratio was measured from 18F-FDG PET for brain glucose metabolism
Through study completion, about 2 years
Functional connectivity
Functional connectivity was measured from fMRI for brain regional interactions
Through study completion, about 2 years
Study Arms (3)
Experimental Group
The experimental group underwent neuropsychological testing, 18F-FDG PET/CT, 3T resting state fMRI examinations.
MRI Control Group
The MRI control group underwent neuropsychological testing and 3T resting state fMRI examinations
PET Control Group
The PET control group underwent 18F-FDG PET/CT examination
Eligibility Criteria
Pediatric patients with childhood epilepsy with centrotemporal spikes
You may qualify if:
- (a) age between 6 and 18 years; (b) 18F-FDG PET examination more than 48 h since the last seizure, (c) no structural abnormalities associated with epilepsy detected on routine MRI
You may not qualify if:
- (a) any history of other neurological or psychiatric disorders; (b) pre-scan plasma glucose level \> 120 mg/dl before 18F-FDG PET/CT examination;(c) any contraindications for MRI examination ; (d) head movement (translation \> 3 mm or rotation \> 3 degree ) during MRI examination
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Nuclear Medicine and PET/CT Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310009, China
Related Publications (1)
Li Y, Zhang T, Feng J, Qian S, Wu S, Zhou R, Wang J, Sa G, Wang X, Li L, Chen F, Yang H, Zhang H, Tian M. Processing speed dysfunction is associated with functional corticostriatal circuit alterations in childhood epilepsy with centrotemporal spikes: a PET and fMRI study. Eur J Nucl Med Mol Imaging. 2022 Jul;49(9):3186-3196. doi: 10.1007/s00259-022-05740-w. Epub 2022 Feb 24.
PMID: 35199226DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 6, 2021
First Posted
July 8, 2021
Study Start
June 1, 2019
Primary Completion
June 1, 2021
Study Completion
June 30, 2021
Last Updated
July 8, 2021
Record last verified: 2021-07
Data Sharing
- IPD Sharing
- Will not share