PDRI Rates Among CAPD Patients at a Tertiary University Hospital: A 5-Year Retrospective Study

NCT04950179 | Completed

• 1 other identifier: PDRI-2020
• Study Type: observational
• Target: 135
• Locations: 1 country
• Sites: 1

Brief Summary

Peritoneal dialysis-related infection is a complication that leads to peritoneal dialysis catheter removal or patient death. The present study aimed to investigate peritoneal dialysis-related infection rates, causative pathogens, appropriation of antibiotic use, treatment outcomes and trend in antimicrobial resistance of causative pathogens.

Conditions

Peritoneal Dialysis-related Infection

Keywords

Peritoneal dialysis-related infection; Infectious peritonitis; Exit-site infection; Tunnel infection; Infection rate

Outcome Measures

Primary Outcomes (2)

• Rate of peritoneal dialysis-related infection

  Retrospective data collection from patients' medical records

  January 1, 2016 to December 31, 2020

• Treatment outcomes of peritoneal dialysis-related infection

  Retrospective data collection from patients' medical records

  January 1, 2016 to December 31, 2020

Secondary Outcomes (2)

• Causative pathogens of peritoneal dialysis-related infection

  January 1, 2016 to December 31, 2020

• Appropriation of antibiotic use in the treatments of peritoneal dialysis-related infection

  January 1, 2016 to December 31, 2020

Interventions

PDRI patients OTHER

The study was conducted by retrospective data collection from medical records of 135 continuous ambulatory peritoneal dialysis (CAPD) patients at Phramongkutklao Hospital from January 1, 2016 to December 31, 2020.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who were undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD) at CAPD clinic, Phramongkutklao Hospital.

You may qualify if:

• Patients who were at least 18 years old.
• Patients who were diagnosed with stage 5 chronic kidney disease (eGFR \< 15 ml/min/1.73m\^2).
• Patients who were undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD) at CAPD clinic, Phramongkutklao Hospital during January 1, 2016 to December 31, 2020.

You may not qualify if:

• Patients with incomplete data records that invalid to include in the process of data analysis
• Patients who were not treated and started their first CAPD at CAPD clinic, Phramongkutklao Hospital.

Sponsors & Collaborators

• Phramongkutklao College of Medicine and Hospital: lead
• Silpakorn University: collaborator

Study Sites (1)

Phramongkutklao Hospital

Ratchathewi, Bangkok, 10400, Thailand

Location

Related Publications (8)

• Luvira V, Satirapoj B, Supasyndh O, Chaiprasert A, Ruangkanchanasetr P, Nata N, Kanjanakul I, Supaporn T, Choovichian P, Bijaphala S, Luvira U, Phiboonbanakit D. A single-centre experience: peritoneal dialysis-related infections in patients on long-term dialysis. J Med Assoc Thai. 2011 Sep;94 Suppl 4:S30-6.

  PMID: 22043564 BACKGROUND

• Kanjanabuch T, Chancharoenthana W, Katavetin P, Sritippayawan S, Praditpornsilpa K, Ariyapitipan S, Eiam-Ong S, Dhanakijcharoen P, Lumlertgul D. The incidence of peritoneal dialysis-related infection in Thailand: a nationwide survey. J Med Assoc Thai. 2011 Sep;94 Suppl 4:S7-12.

  PMID: 22043560 BACKGROUND

• Perl J, Fuller DS, Bieber BA, Boudville N, Kanjanabuch T, Ito Y, Nessim SJ, Piraino BM, Pisoni RL, Robinson BM, Schaubel DE, Schreiber MJ, Teitelbaum I, Woodrow G, Zhao J, Johnson DW. Peritoneal Dialysis-Related Infection Rates and Outcomes: Results From the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS). Am J Kidney Dis. 2020 Jul;76(1):42-53. doi: 10.1053/j.ajkd.2019.09.016. Epub 2020 Jan 10.

  PMID: 31932094 BACKGROUND

• Wang HH, Huang CH, Kuo MC, Lin SY, Hsu CH, Lee CY, Chiu YW, Chen YH, Lu PL. Microbiology of peritoneal dialysis-related infection and factors of refractory peritoneal dialysis related peritonitis: A ten-year single-center study in Taiwan. J Microbiol Immunol Infect. 2019 Oct;52(5):752-759. doi: 10.1016/j.jmii.2018.10.013. Epub 2019 Jan 8.

  PMID: 30665844 BACKGROUND

• Chen HC, Shieh CC, Sung JM. Increasing Staphylococcus Species Resistance in Peritoneal Dialysis-Related Peritonitis over a 10-Year Period in a Single Taiwanese Center. Perit Dial Int. 2018 Jul-Aug;38(4):266-270. doi: 10.3747/pdi.2017.00226.

  PMID: 29987065 BACKGROUND

• Li PK, Szeto CC, Piraino B, Bernardini J, Figueiredo AE, Gupta A, Johnson DW, Kuijper EJ, Lye WC, Salzer W, Schaefer F, Struijk DG; International Society for Peritoneal Dialysis. Peritoneal dialysis-related infections recommendations: 2010 update. Perit Dial Int. 2010 Jul-Aug;30(4):393-423. doi: 10.3747/pdi.2010.00049. No abstract available.

  PMID: 20628102 BACKGROUND

• Szeto CC, Li PK, Johnson DW, Bernardini J, Dong J, Figueiredo AE, Ito Y, Kazancioglu R, Moraes T, Van Esch S, Brown EA. ISPD Catheter-Related Infection Recommendations: 2017 Update. Perit Dial Int. 2017 Mar-Apr;37(2):141-154. doi: 10.3747/pdi.2016.00120. No abstract available.

  PMID: 28360365 BACKGROUND

• Li PK, Szeto CC, Piraino B, de Arteaga J, Fan S, Figueiredo AE, Fish DN, Goffin E, Kim YL, Salzer W, Struijk DG, Teitelbaum I, Johnson DW. ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment. Perit Dial Int. 2016 Sep 10;36(5):481-508. doi: 10.3747/pdi.2016.00078. Epub 2016 Jun 9. No abstract available.

  PMID: 27282851 BACKGROUND

Study Officials

• Pamila Tasanavipas, MD

  Phramongkutklao Hospital and College of Medicine

  STUDY CHAIR

• Daraporn Rungprai, BCP

  Faculty of Pharmacy, Silpakorn University

  STUDY DIRECTOR

• Vorada Pengsong

  Faculty of Pharmacy, Silpakorn University

  PRINCIPAL INVESTIGATOR

• Vattanai Dhamnimitchok

  Faculty of Pharmacy, Silpakorn University

  PRINCIPAL INVESTIGATOR

• Vilai Wisuthip

  Faculty of Pharmacy, Silpakorn University

  PRINCIPAL INVESTIGATOR

• Supichaya Hluangbumroong

  Faculty of Pharmacy, Silpakorn University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 25, 2021
• First Posted: July 6, 2021
• Study Start: February 24, 2021
• Primary Completion: March 11, 2021
• Study Completion: April 14, 2021
• Last Updated: July 12, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)