Iron Status in BTM With Blood Transfusion

NCT04947540 | Unknown

• 1 other identifier: IS in BTM patients
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

To assess the possible role of iron overload as a cause of liver dysfunction in thalassemic childrens receiving multiple blood transfusion and its correlation with serum aminotransferases.

Conditions

Beta-Thalassemia

Outcome Measures

Primary Outcomes (1)

• Hematological and biochemical markers of Iron status in thalassemic children receiving multiple blood transfusion

  Assessment the possible role of iron overload as a cause of liver dysfunction in thalassemic childrens receiving multiple blood transfusion and its correlation with serum aminotransferases.

  baseline

Eligibility Criteria

• Age: 5 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

all cases diagnosed as thalassemia major attending to thalassemic center at hematological department at Assuit university childern hospital.

You may qualify if:

• Thalassemic patients of both sex.
• Beta-thalassemia major patients diagnosed Clinical and laboratory .
• Age 5 : 18 years.
• Undergoing multiple blood transfusion.

You may not qualify if:

• Age less than 5 years.
• Acute illness as fever and infections.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Al-Moshary M, Imtiaz N, Al-Mussaed E, Khan A, Ahmad S, Albqami S. Clinical and Biochemical Assessment of Liver Function Test and Its Correlation with Serum Ferritin Levels in Transfusion-dependent Thalassemia Patients. Cureus. 2020 Apr 7;12(4):e7574. doi: 10.7759/cureus.7574.

  PMID: 32391223 BACKGROUND

• Amjad F, Fatima T, Fayyaz T, Khan MA, Qadeer MI. Novel genetic therapeutic approaches for modulating the severity of beta-thalassemia (Review). Biomed Rep. 2020 Nov;13(5):48. doi: 10.3892/br.2020.1355. Epub 2020 Sep 2.

  PMID: 32953110 BACKGROUND

• Salama KM, Ibrahim OM, Kaddah AM, Boseila S, Ismail LA, Hamid MM. Liver Enzymes in Children with beta-Thalassemia Major: Correlation with Iron Overload and Viral Hepatitis. Open Access Maced J Med Sci. 2015 Jun 15;3(2):287-92. doi: 10.3889/oamjms.2015.059. Epub 2015 May 28.

  PMID: 27275237 BACKGROUND

MeSH Terms

Conditions

beta-Thalassemia

Condition Hierarchy (Ancestors)

Thalassemia; Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemoglobinopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Mohamed M Ghazally, professor

  Egypt

  STUDY DIRECTOR

Central Study Contacts

Rehab M Rashed, pediatrician

CONTACT

01064959241; rhabrashed950@gmail.com

Hekma S Farghaly, Assist. prof

CONTACT

01091251040; Hekma.osman@med.au.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: June 24, 2021
• First Posted: July 1, 2021
• Study Start: July 1, 2021
• Primary Completion: July 1, 2022
• Study Completion: March 1, 2023
• Last Updated: July 19, 2021

Record last verified: 2021-06