CONNACT OA Knee Cohort

NCT04942236 | Unknown

• 1 other identifier: WHC/2020-00076
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 3

Brief Summary

CONNACT OA knee cohort is a prospective longitudinal cohort study where we aim to collect sociodemographic, psychosocial, clinical, health utilization and cost data in order to better understand the Asian OA knee cohort and investigate for prognostic variables that can potentially influence a patients clinical outcome and treatment decisions. In addition, the CONNACT OA knee cohort will form the basis for a cohort multiple randomized control trial (cmRCT) study design where multiple interventions can be tested in a randomized fashion. Each intervention is offered to a randomly selected sample of patients eligible for that intervention, who are then compared with the rest of the eligible patients from the cohort that are still being treated as usual.

Conditions

Osteoarthritis, Knee

Outcome Measures

Primary Outcomes (4)

• Knee Injury and Osteoarthritis Outcomes Score (KOOS-12)

  Derived from the original 42-item Knee injury and Osteoarthritis Outcome Score (KOOS), KOOS-12 reduces respondent burden by 70% from the original KOOS while providing scale scores for knee-specific Pain, Function and QOL, along with a summary measure of overall knee impact. The KOOS sub scales are scored using the method of summated ratings and transformed to range from 0 to 100, with 0 representing extreme knee problems and 100 representing no knee problem. The KOOS-12 Summary knee impact score is calculated as the average of the KOOS-12 Pain, KOOS-12 Function and KOOS-12 QOL scale scores. It also ranges from 0 to 100, where 0 is the worst possible and 100 is the best possible score.

  Baseline

• Knee Injury and Osteoarthritis Outcomes Score (KOOS-12)

  Derived from the original 42-item Knee injury and Osteoarthritis Outcome Score (KOOS), KOOS-12 reduces respondent burden by 70% from the original KOOS while providing scale scores for knee-specific Pain, Function and QOL, along with a summary measure of overall knee impact. The KOOS sub scales are scored using the method of summated ratings and transformed to range from 0 to 100, with 0 representing extreme knee problems and 100 representing no knee problem. The KOOS-12 Summary knee impact score is calculated as the average of the KOOS-12 Pain, KOOS-12 Function and KOOS-12 QOL scale scores. It also ranges from 0 to 100, where 0 is the worst possible and 100 is the best possible score.

  Change from Baseline to 3 months

• Knee Injury and Osteoarthritis Outcomes Score (KOOS-12)

  Derived from the original 42-item Knee injury and Osteoarthritis Outcome Score (KOOS), KOOS-12 reduces respondent burden by 70% from the original KOOS while providing scale scores for knee-specific Pain, Function and QOL, along with a summary measure of overall knee impact. The KOOS sub scales are scored using the method of summated ratings and transformed to range from 0 to 100, with 0 representing extreme knee problems and 100 representing no knee problem. The KOOS-12 Summary knee impact score is calculated as the average of the KOOS-12 Pain, KOOS-12 Function and KOOS-12 QOL scale scores. It also ranges from 0 to 100, where 0 is the worst possible and 100 is the best possible score.

  Change from Baseline to 6 months

• Knee Injury and Osteoarthritis Outcomes Score (KOOS-12)

  Derived from the original 42-item Knee injury and Osteoarthritis Outcome Score (KOOS), KOOS-12 reduces respondent burden by 70% from the original KOOS while providing scale scores for knee-specific Pain, Function and QOL, along with a summary measure of overall knee impact. The KOOS sub scales are scored using the method of summated ratings and transformed to range from 0 to 100, with 0 representing extreme knee problems and 100 representing no knee problem. The KOOS-12 Summary knee impact score is calculated as the average of the KOOS-12 Pain, KOOS-12 Function and KOOS-12 QOL scale scores. It also ranges from 0 to 100, where 0 is the worst possible and 100 is the best possible score.

  Change from Baseline to 12 months

Secondary Outcomes (16)

• Knee Injury and Osteoarthritis Outcomes Score (KOOS) subscales - Pain, Function, QoL

  Baseline

• Knee Injury and Osteoarthritis Outcomes Score (KOOS) subscales - Pain, Function, QoL

  Change from Baseline to 3 months

• Knee Injury and Osteoarthritis Outcomes Score (KOOS) subscales - Pain, Function, QoL

  Change from Baseline to 6 months

• Knee Injury and Osteoarthritis Outcomes Score (KOOS) subscales - Pain, Function, QoL

  Change from Baseline to 12 months

• EuroQol-5 Dimensions (EQ-5D)

  Baseline

Other Outcomes (50)

• OsteoArthritis Quality Indicator (OA QI)

  Baseline

• University of California, Los Angeles (UCLA) activity score

  Baseline

• University of California, Los Angeles (UCLA) activity score

  Change from Baseline to 3 months

Eligibility Criteria

• Age: 46 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Knee Osteoarthritis patients for conservative treatment

You may qualify if:

• Knee Osteoarthritis (based on NICE guidelines)
• Age \> 45 years
• Community ambulator with or without walking aid
• Conversant in English or Chinese

You may not qualify if:

• Alternative diagnosis to Knee OA e.g. referred pain from spine or hip
• Other forms of knee arthritis e.g. inflammatory, post-traumatic
• Moderate to severe cognitive impairment e.g. dementia
• Previous knee arthroplasty
• Wheelchair bound patients
• Medical conditions that will medically interfere with rehabilitation involvement e.g. decompensated heart failure, stroke with significant deficit, end stage renal failure

Sponsors & Collaborators

• Tan Tock Seng Hospital: lead
• National Healthcare Group, Singapore: collaborator
• Khoo Teck Puat Hospital: collaborator
• Woodlands Health Campus: collaborator

Study Sites (3)

Khoo Teck Puat Hospital

Singapore, Singapore

Location

St Luke's Eldercare (AMK Polyclinic, Hougang Central, Nee Soon Central)

Singapore, Singapore

Location

Tan Tock Seng Hospital

Singapore, Singapore

Location

Related Publications (2)

• Sahrin R, Ng CJY, Lim CJ, Goh ZZS, Pua YH, Tan BY. Exploring the role of the built environment and psychosocial mediators on knee function in knee osteoarthritis patients in Singapore: a cross-sectional study. BMJ Open. 2024 Nov 2;14(11):e082625. doi: 10.1136/bmjopen-2023-082625.

  PMID: 39488423 DERIVED

• Tan BY, Goh ZZS, Lim CJ, Pereira MJ, Yang SY, Tan KG, Tan ACK, Liang P, Abbott JH, Briggs AM, Hunter DJ, Skou ST, Thumboo J, Car J. Singapore KneE osTeoarthritis CoHort (SKETCH): protocol for a multi-centre prospective cohort study. BMC Musculoskelet Disord. 2023 Feb 7;24(1):104. doi: 10.1186/s12891-023-06207-1.

  PMID: 36750930 DERIVED

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Bryan Tan

  Tan Tock Seng Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Bryan Tan

CONTACT

63577713; bryan_tan@whc.sg

Pei Gin Ong

CONTACT

63577713

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Consultant

Study Record Dates

• First Submitted: June 8, 2021
• First Posted: June 28, 2021
• Study Start: June 30, 2021
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2024
• Last Updated: June 28, 2021

Record last verified: 2021-06

Locations

SG (3)