Non-risk Based Lang Cancer Screening With a One-off LDCT
Non-risk Based Lung Cancer Screening With One-time Low-dose Computed Tomography: a Prospective Cohort Study
1 other identifier
interventional
11,000
1 country
1
Brief Summary
Guangzhou Lung-Care Project is a single-arm, prospective cohort study using one-time low-dose computed tomography for the early detection of LC, recruiting residents aged 40-74 years from four communities in Guangzhou between 2015 and 2021.The primary outcome was LC detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases, and to investigate the various factors associated with the development of LC.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable lung-cancer
Started Dec 2015
Longer than P75 for not_applicable lung-cancer
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 12, 2015
CompletedFirst Submitted
Initial submission to the registry
June 12, 2021
CompletedFirst Posted
Study publicly available on registry
June 24, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2026
ExpectedJanuary 9, 2024
January 1, 2024
10 years
June 12, 2021
January 7, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
The detection rate of lung cancer
Lung cancer detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases.
11 years
To investigate the various factors associated with the development of lung cancer
To investigate the various factors associated with the development of lung cancer
11 years
Secondary Outcomes (2)
Detection rates of lung cancer and the proportion of stage I lung cancer cases between "high-risk" and "non-high-risk" groups
11 years
Cost-effectiveness ratio (costs of examinations, diagnoses, and treatments)
11 years
Study Arms (1)
Screening group
EXPERIMENTALInterventions
The Low-dose computed tomography is conducted according to the guideline suggested by American College of Radiology.
Eligibility Criteria
You may qualify if:
- Minimum age of 40 years among the residents in Guangzhou
You may not qualify if:
- Persons who had a diagnosis or treatment related to LC within the past 5 years, had undergone chest CT within the past year, or had significant cancer-related symptoms (e.g., hemoptysis, dyspnea, inability to climb two flights of stairs).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, 510120, China
Related Publications (1)
Ye W, Fu W, Li C, Li J, Xiong S, Cheng B, Xu B, Wang Q, Feng Y, Chen P, He J, Liang W. Diameter thresholds for pure ground-glass pulmonary nodules at low-dose CT screening: Chinese experience. Thorax. 2025 Jan 17;80(2):76-85. doi: 10.1136/thorax-2024-221642.
PMID: 39689940DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Wenhua Liang, MD
The First Affiliated Hospital of Guangzhou Medical University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- SCREENING
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
June 12, 2021
First Posted
June 24, 2021
Study Start
December 12, 2015
Primary Completion
December 1, 2025
Study Completion (Estimated)
December 1, 2026
Last Updated
January 9, 2024
Record last verified: 2024-01