D-dimer Prognostic Marker of Cerebral Infarction After Revascularization Procedure

NCT04938479 | Unknown

• 1 other identifier: PI2020_843_0159
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Cerebral infarction is the leading cause of acquired disability in adults. Absence of biological marker used in current practice and identified as a prognostic factor for recovery. D-dimers are degradation products of stabilized fibrin translating an activation of coagulation whatever the cause. Studies have shown that increased D-dimer levels in patients with MI is associated with a higher mortality rate, the link with post-intervention non-revascularization has been demonstrate. The purpose of this project is to search for a correlation between the level of D-dimer and the degree of recovery evaluated by the NIHSS score

Conditions

Cerebral Infarction; Cerebral Infarction Recovery

Keywords

Cerebral Infarction; cerebral infarction recovery

Outcome Measures

Primary Outcomes (4)

• Correlation between D-dimer concentration and NIHSS score

  NIHSS score is based on the clinical neurological examination of the patient. Validated by the scientific community of vascular neurology, among other things in projective clinical research. This score has high inter-observer reproducibility Expressed quantitatively on a scale of 0 to 42 for the NIHSS score A high value of the NIHSS score indicates poor recovery.

  3 months

• Correlation between D-dimer concentration and NIHSS score

  NIHSS score is based on the clinical neurological examination of the patient. Validated by the scientific community of vascular neurology, among other things in projective clinical research. This score has high inter-observer reproducibility Expressed quantitatively on a scale of 0 to 42 for the NIHSS score A high value of the NIHSS score indicates poor recovery.

  6 months

• Correlation between D-dimer concentration and the Rankin score

  Rankin Scale collected by the neurologist in consultation 3-6 months post stroke. Expressed quantitatively on a scale of 0 to 6 for the Rankin scale. A high value of the Rankin scale indicates poor recovery.

  3 months

• Correlation between D-dimer concentration and the Rankin score

  Rankin Scale collected by the neurologist in consultation 3-6 months post stroke. Expressed quantitatively on a scale of 0 to 6 for the Rankin scale. A high value of the Rankin scale indicates poor recovery.

  6 months

Interventions

blood sample BIOLOGICAL

D-dimer measurement in blood sample

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients under 65 years of age who have presented a heart attack brain and undergoing a revascularization procedure

You may qualify if:

• Patients aged 18 to 65
• Cerebral infarctions undergoing a revascularization procedure by thrombolysis and / or thrombectomy, at the Amiens University Hospital between January 2015 and December 2020.
• Patients having benefited from a D-dimer assay (during their stay)

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens

Amiens, 80480, France

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

D-Dimer measurement in blood sample

MeSH Terms

Conditions

Cerebral Infarction

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Brain Infarction; Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke; Vascular Diseases; Cardiovascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Central Study Contacts

Audrey ARNOUX-COURSELLE, MD

CONTACT

0322668000; arnoux.audrey@chu-amiens.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 17, 2021
• First Posted: June 24, 2021
• Study Start: June 15, 2021
• Primary Completion: September 1, 2023
• Study Completion: September 1, 2023
• Last Updated: May 10, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)