NCT04935814|CompletedPhase 4
Cardiac Output Response to Vasopressin Infusion In Abdominal Surgery Patients Under Mechanical Ventilation
CORVaso
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CORVaso
Sponsor study identifier
interventional
20
1 country
1
Study Start
June 9, 2021
Actual (reported)Primary Completion
August 2, 2022
Actual (reported)Study Completion
August 2, 2022
Actual (reported)In this study, the investigators propose to explore the hemodynamic variations induced by vasopressin and its influence on cardiac output, mean systemic pressure, and venous return resistance measured through cardiopulmonary interactions, according to the approach proposed by Guyton, in patients undergoing major abdominal surgeries.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2, 2022
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 9, 2021
Actual (reported)June 15, 2021
Actual (reported)June 23, 2021
Actual (reported)August 2, 2022
Actual (reported)August 2, 2022
Actual (reported)Variation of cardiac output after an infusion of vasopressin at different levels of cardiac preload
Using a thermodilution method, cardiac output will be measured and recorded at different levels of cardiac preload obtained by changing patient's position (Trendelenburg, anti-Trendelenburg and supine position).
15 minutes after position change
Variation of mean systemic filling pressure and venous return after an infusion of vasopressin at different levels of cardiac preload
15 minutes after position change
Variation of central venous pressure after an infusion of vasopressin at different levels of cardiac preload
15 minutes after position change
After general anesthesia, patients will receive a continuous infusion of vasopressin in order to improve mean arterial pressure by 20 mmHg.
Once vasopressin infusion started, patients positions will be randomized: Trendelenburg (-30°), anti Trendelenburg (+30°) and supine position (0°).
CHU
Clermont-Ferrand, France
Thomas Godet
University Hospital, Clermont-Ferrand
20 participants (actual enrollment reported by the registry).
First Submitted
June 15, 2021
First Posted
June 23, 2021
Study Start
Safety and Efficacy of Maintenance of Etomidate in General Anesthesia
Contact the study team to confirm eligibility.
June 9, 2021
Actual (reported)Primary Completion
August 2, 2022
Actual (reported)Study Completion
August 2, 2022
Actual (reported)Last Updated
December 5, 2022
Record last verified: 2022-12
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