Musculoskeletal Symptoms in Post Acute Covid-19 Patients

NCT04932889 | Completed

• 1 other identifier: EskisehirCityH
• Study Type: observational
• Target: 280
• Locations: 1 country
• Sites: 1

Brief Summary

The patients whose musculoskeletal symptoms initiated or aggravated with Covid-19, were compared with the patients whose musculoskeletal symptoms did not change with Covid-19. The variables; the demographic and treatment datas, admission symptoms, post acute-Covid-19 symptoms, laboratory, chest computed tomography findings.

Conditions

Covid19; Musculoskeletal Abnormalities

Outcome Measures

Primary Outcomes (9)

• Rate of back pain

  given as percentage %

  Baseline

• Chest computed tomography

  Presence of covid-19 findings in chest computed tomography (covid findings positive or negative)

  Baseline

• Rate of low-back pain

  given as percentage %

  Baseline

• Rate of fatigue

  given as percentage %

  Baseline

• Rate of neck pain

  given as percentage %

  Baseline

• Rate of dyspnea

  given as percentage %

  baseline

• Rate of joint pain

  given as percentage %

  Baseline

• Rate of chest pain

  given as percentage %

  Baseline

• Rate of myalgia

  given as percentage %

  Baseline

Secondary Outcomes (10)

• age

  Baseline

• Weight

  Baseline

• gender

  Baseline

• Duration after the onset of covid-19

  Baseline

• Lymhocyte levels

  Baseline

Study Arms (2)

Change

the patients whose musculoskeletal symptoms initiated or aggravated with Covid-19 (n=240)

Other: Survey; Other: Laboratory parameters; Other: chest computed tomography

No change

the patients whose musculoskeletal symptoms did not change with Covid-19 (n=40)

Other: Survey; Other: Laboratory parameters; Other: chest computed tomography

Interventions

Survey OTHER

A detailed anamnesis was retrospectively recorded about age, gender, body mass index, education, working, the presence of any chronic disease (diabetes mellitus, hypertension, chronic obstructive pulmonary disease, cardiac disease, cancer, rheumatological disease…), smoking, duration of symptoms, usage of supplementing vitamins such as vitamin D,C, zinc…, treatment place (home quarantine, hospital, intensive care unit), duration of home quarantine and hospital treatment, the number of months since the onset of Covid-19 symptoms, usage of anticoagulants, treatment drugs such as hydroxychloroquine, favipiravir. Also the symptoms during the period of Covid-19 infection were recorded from patient files; cough, fever, dyspnea, chest pain, loss of smell and taste, sore throat, headache, no symptom, musculoskeletal symptoms such as: muscle, low back, back, joint pain.

Change; No change

Laboratory parameters OTHER

The laboratory values of 182 patients, presence of chest computed tomography findings of 206 patients and symptoms of all patients during the period of Covid-19 infection, were retrospectively recorded. Laboratory values of hemoglobin, leucocyte, lymphocyte, platelet, C-reactive protein, erythrocyte sedimentation rate, ferritin, d-dimer, were recorded.

Change; No change

chest computed tomography OTHER

Typical findings of chest CT were; bilateral, multifocal, peripheral ground glass opacities with/without consolidation, including the fissures, close to visceral pleural surfaces. Covid-19 Reporting and Data System (CO-RADS) was used for chest CT. CO-RADS assigns scores from 1 (very low suspicion of Covid-19) to 5 (very high suspicion of Covid-19).

Change; No change

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This retrospective cross-sectional study was carried out with the records of 280 post Covid-19 patients who admitted to the physical medicine and rehabilitation outpatient clinic between December 2020 and May 2021.

You may qualify if:

• Being 18 years or older
• Having Covid-19 treatment (home quarantine / hospital / intensive care unit) according to a positive polymerase chain reaction (PCR) test in a nasopharyngeal + oropharyngeal swab or chest CT.

You may not qualify if:

• Patients who did not have musculoskeletal symptom records (admission symptoms and musculoskeletal symptoms such as; fatigue, spine / joint /muscle pain/ numbness) in patients files
• Acute Covid-19 patients whose symptoms started less than 1 month

Sponsors & Collaborators

• Eskisehir City Hospital: lead

Study Sites (1)

Eskişehir City Hospital

Eskişehir, Turkey (Türkiye)

Location

MeSH Terms

Conditions

COVID-19; Musculoskeletal Abnormalities

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Musculoskeletal Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Fulya Bakılan

  Eskişehir City Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist in physical medicine and rehabilitation

Study Record Dates

• First Submitted: June 14, 2021
• First Posted: June 21, 2021
• Study Start: June 11, 2021
• Primary Completion: June 13, 2021
• Study Completion: June 14, 2021
• Last Updated: June 21, 2021

Record last verified: 2021-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)