Study Stopped
The vaccination campaign started before the approval of the ethics committee was obtained. The study is therefore no longer of interest to be carried out.
Level of Immunity, Neutralization of the COVID-19 Virus and Reinfections in Residents of 2 Migrant Workers' Residences
Determination of the Level of Immunity, Neutralization of the SARS-COV-2 Virus and Reinfections in Residents of 2 Migrant Workers' Residences 10 Months Apart
1 other identifier
observational
N/A
1 country
2
Brief Summary
A previous seroprevalence survey showed very high seroprevalence levels among residents of the two among the residents of the two migrant workers' hostels surveyed, indicating a high level of circulation of the virus SARS-COV-2 during the 1st wave of COVID-19. The constitution of a cohort after the event would be an opportunity to obtain opportunity to obtain answers to crucial questions: duration of immunity, potential reinfections potential reinfections, potential re-clustering. Going back to check the serological status seems feasible, especiallyespecially in the Foyers de Travailleurs Migrants (high probability of finding the participants). There is an obvious scientific interest around the duration of immunity and reinfections in a population highly exposed during the first wave. Several articles document the decline of IgG antibodies in the months following an infection, but very few infection, but very few evaluate the protective character in the medium term (\>=6 months), especially in asymptomatic individuals. We are also concerned about the circulation of We are also concerned about the circulation of new variants and the immunity acquired after infection in residents. To date, no study on the duration of immunity has been conducted in migrant worker's residences.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Jun 2021
Shorter than P25 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 1, 2021
CompletedStudy Start
First participant enrolled
June 14, 2021
CompletedFirst Posted
Study publicly available on registry
June 21, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 25, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
July 2, 2021
CompletedJune 21, 2021
June 1, 2021
11 days
June 1, 2021
June 17, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Level and quality of current humoral immune protection in the residents of the two migrant workers' residences
To assess the level and quality of current humoral immune protection in the residents of the two migrant workers' residences in Villemomble and Montreuil who were included in the 1st seroprevalence study in July 2020, approximately 10 months later (May 2021)
15 days
Secondary Outcomes (3)
Immunity and protection
15 days
New infections and screening
15 days
COVID Vaccination
15 days
Study Arms (1)
migrant worker residents
The target population will be the 124 residents in the 2 migrant worker residences who were included in the previous seroprevalence study and those who arrived at the 2 residences since September 1st, 2020
Interventions
Serological, viral RNA and antigenic test
Eligibility Criteria
residents of 2 Migrant Workers
You may qualify if:
- All individuals who consented to participate in the 1st study and who consent to participate in this study
- All individuals 18 years of age or older not residing in the 2 MWRs in July 2020 and permanently living in the MWR since September 2020 who consent to participate in this study
You may not qualify if:
- Unwillingness to provide informed consent
- Unwillingness to provide blood
- Contraindication to venepuncture
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Epicentrelead
- Medecins Sans Frontieres, Netherlandscollaborator
- Institut Pasteurcollaborator
- Agence Regionale de Sante d'Ile de Francecollaborator
Study Sites (2)
Foyer de travailleurs migrants
Montreuil, Île-de-France Region, 93, France
Foyer de travailleurs migrants
Villemomble, Île-de-France Region, 93, France
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Elisabeth POULET, MD
Epicentre
Study Design
- Study Type
- observational
- Observational Model
- ECOLOGIC OR COMMUNITY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 1, 2021
First Posted
June 21, 2021
Study Start
June 14, 2021
Primary Completion
June 25, 2021
Study Completion
July 2, 2021
Last Updated
June 21, 2021
Record last verified: 2021-06
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- CSR
The research team will develop a range of activities to disseminate the study findings. These dissemination activities will be coordinated by MSF and Epicentre. The results will be presented in an internal report and an external report for the Ministry of Health (MoH), the French National Public Health Agency and Institute Pasteur. An abstract of the findings will be submitted for presentation at a scientific conference, and at least one manuscript will be submitted for publication in a peer-reviewed scientific journal. The findings of the survey will also be used for advocacy purposes, in coordination with community leaders of participating communities. The results of the survey (lay version of the report), and their possible use for advocacy / communication, will be shared with the staff, resident representatives and residents of the MWRs, whether or not they actually participated in the study.