Risk Factors of ICU-acquired Weakness

NCT04932330 | Unknown

• 1 other identifier: 2021-0041
• Study Type: observational
• Target: 85
• Locations: 1 country
• Sites: 1

Brief Summary

We conducted a retrospective study of critical ill patients who used ECMO during their ICU stay. ICU-AW was diagnosed at the time when patients discharged and had a Medical Research Council (MRC) sum score \< 48 out of a maximal score of 60. We divided patients to ICU-acquired weakness group and no ICU-acquired weakness group and compared their clinical characteristics. Baseline characteristics and therapy details were collected from the case report forms and inspection reports. Univariable analysis and logistic regression analysis were used to analyze clinical characteristics of individuals and to find risk factors of ICU-AW.

Conditions

ICU Acquired Weakness

Keywords

ICU Acquired Weakness; Extracorporeal Membrane Oxygenation

Outcome Measures

Primary Outcomes (1)

• Differences between ICU-acquired weakness in patients receiving extracorporeal membrane oxygenation support

  We compared the clinical characteristics between ICU-acquired weakness group and no ICU-acquired weakness group by univariate analysis . Then we used logistic regression analysis and found out differences of ICU-acquired weakness.

  1 day

Secondary Outcomes (1)

• Frequency of ICU-acquired weakness in in patients receiving extracorporeal membrane oxygenation support

  1 day

Study Arms (2)

ICU-acquired weakness group

Patients receiving extracorporeal membrane oxygenation support who had a Medical Research Council (MRC) sum score \< 48 out of a maximal score of 60 when discharged.

no ICU-acquired weakness group

Patients receiving extracorporeal membrane oxygenation support who had a Medical Research Council (MRC) sum score ≥ 48 out of a maximal score of 60 when discharged.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

There were 85 patients used extracorporeal membrane oxygenationbetween March 2017 to March 2020. Among the 85 patients, 22 patients presented exclusion criteria and 63 patients were included in the final analysis.

You may qualify if:

• Critical ill patients who used extracorporeal membrane oxygenation during their ICU stay. Patients were recruited from the general ICU of the second affiliated hospital of Zhejiang University, between March 2017 to March 2020.

You may not qualify if:

• Patients who was less than 18 years old, had been proven or suspected neurological impairment, using extracorporeal membrane oxygenation less than 24 hours, severe head or spinal cord injury and pregnant woman.

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Study Sites (1)

Xinyi Chen

Hangzhou, Please Select, 310000, China

RECRUITING

Central Study Contacts

xinyi chen, master

CONTACT

19858875700; chenxinyi0323@zju.edu.cn

man huang, phD

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 1, 2021
• First Posted: June 21, 2021
• Study Start: March 1, 2017
• Primary Completion: March 1, 2020
• Study Completion: June 1, 2022
• Last Updated: June 21, 2021

Record last verified: 2021-06

Data Sharing

• IPD Sharing: Will share

Locations

CN (1)