Myofascial Pain and Central Sensitization
The Impact of Nociplastic Pain Features on the Response to Physical Therapy in Patients With Primary Myofascial Pain: A Pilot Study.
1 other identifier
observational
30
1 country
1
Brief Summary
This prospective, observational cohort pilot study compared pain phenotyping and functional measures in 30 participants with non-acute neck and/or shoulder girdle pain consistent with primary myofascial pain at 3-months following a physical therapy referral to study the impact of their baseline degree of pain amplification.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started May 2016
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 2, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 23, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
November 23, 2019
CompletedFirst Submitted
Initial submission to the registry
June 10, 2021
CompletedFirst Posted
Study publicly available on registry
June 18, 2021
CompletedSeptember 17, 2025
September 1, 2025
3.6 years
June 10, 2021
September 10, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Change in Neck Disability Index
Function neck scale with a total possible score of 50 indicating worse function compared to a score of 0.
Baseline to 3 months
Secondary Outcomes (1)
Change in PEG Score
Baseline to 3 months
Study Arms (1)
Patients with myofascial pain having centralized pain features
Adult patients with myofascial pain having centralized pain features who will be undergoing physical therapy
Interventions
Physical therapy for chronic upper quarter myofascial pain syndrome, as prescribed by the patients' physicians
Eligibility Criteria
Participants were drawn from new patients evaluated at a tertiary care spine and musculoskeletal clinic.
You may qualify if:
- English-speaking participants
- Diagnosed by their physician with non-acute (more than two weeks) neck and/or shoulder girdle primary myofascial pain
- Referred to a physical therapy treatment.
You may not qualify if:
- Use of chronic high-dose opioid medication greater than 100 mg oral morphine equivalents per day.
- Individuals receiving or applying for compensation or disability.
- The inability to provide informed consent.
- Severe physical impairment (e.g., blindness, deafness)
- Co-morbid medical condition limiting function (e.g., malignant cancer)
- Reported illicit drug use
- Severe psychiatric condition that would limit judgment.
- Lack of internet access.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Michigan
Ann Arbor, Michigan, 48108, United States
Related Publications (1)
Kohns DJ, Scott R, Castellanos J, Scribner D, Hodges R, Clauw DJ. The impact of nociplastic pain features on the response to physical therapy in patients with primary myofascial pain. J Back Musculoskelet Rehabil. 2022;35(5):1143-1151. doi: 10.3233/BMR-210244.
PMID: 35213348RESULT
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
David J Kohnsd, DO
University of Michigan
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
June 10, 2021
First Posted
June 18, 2021
Study Start
May 2, 2016
Primary Completion
November 23, 2019
Study Completion
November 23, 2019
Last Updated
September 17, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will not share