A Study in Healthy Men to Find the Best Formulation of BI 685509 and to Test How it is Taken up in the Body

NCT04926246 | Completed Phase 1 FDA Drug

• 1 other identifier: 1366-0024
• Study Type: interventional
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of this trial is to select a formulation and to optimize the identified formulation of BI 685509, if needed.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Area under the concentration-time curve of BI 685509 in plasma over the time interval from 0 extrapolated to infinity (AUC0-∞)

  up to 5 days

Secondary Outcomes (1)

• Area under the concentration-time curve of BI 685509 in plasma over the time interval from 0 to the last quantifiable data point (AUC0-tz)

  up to 5 days

Study Arms (13)

Part 1: R1-T2-T4-T1-T3

EXPERIMENTAL

Drug: R1: Reference Product X; Drug: T1: Test Product M; Drug: T2: Test Product N; Drug: T3: Test Product O; Drug: T4: Test Product O

Part 1: T1-T4-T2-T3-R1

EXPERIMENTAL

Drug: R1: Reference Product X; Drug: T1: Test Product M; Drug: T2: Test Product N; Drug: T3: Test Product O; Drug: T4: Test Product O

Part 1: T2-T1-T3-R1-T4

EXPERIMENTAL

Drug: R1: Reference Product X; Drug: T1: Test Product M; Drug: T2: Test Product N; Drug: T3: Test Product O; Drug: T4: Test Product O

Part 1: T3-R1-T1-T4-T2

EXPERIMENTAL

Drug: R1: Reference Product X; Drug: T1: Test Product M; Drug: T2: Test Product N; Drug: T3: Test Product O; Drug: T4: Test Product O

Part 1: T4-T3-R1-T2-T1

EXPERIMENTAL

Drug: R1: Reference Product X; Drug: T1: Test Product M; Drug: T2: Test Product N; Drug: T3: Test Product O; Drug: T4: Test Product O

Part 2: R2-T7-T6-T5

EXPERIMENTAL

Drug: R2: Reference Product Y; Drug: T5: Test Product P; Drug: T6: Test Product P; Drug: T7: Test Product Q

Part 2: T5-T6-T7-R2

EXPERIMENTAL

Drug: R2: Reference Product Y; Drug: T5: Test Product P; Drug: T6: Test Product P; Drug: T7: Test Product Q

Part 2: T6-T5-R2-T7

EXPERIMENTAL

Drug: R2: Reference Product Y; Drug: T5: Test Product P; Drug: T6: Test Product P; Drug: T7: Test Product Q

Part 2: T7-R2-T5-T6

EXPERIMENTAL

Drug: R2: Reference Product Y; Drug: T5: Test Product P; Drug: T6: Test Product P; Drug: T7: Test Product Q

Part 3: R3-T10-T9-T8

EXPERIMENTAL

Drug: R3: Reference Product Z; Drug: T8: Test Product S; Drug: T9: Test Product S; Drug: T10: Test Product U

Part 3: T8-T9-T10-R3

EXPERIMENTAL

Drug: R3: Reference Product Z; Drug: T8: Test Product S; Drug: T9: Test Product S; Drug: T10: Test Product U

Part 3: T9-T8-R3-T10

EXPERIMENTAL

Drug: R3: Reference Product Z; Drug: T8: Test Product S; Drug: T9: Test Product S; Drug: T10: Test Product U

Part 3: T10-R3-T8-T9

EXPERIMENTAL

Drug: R3: Reference Product Z; Drug: T8: Test Product S; Drug: T9: Test Product S; Drug: T10: Test Product U

Interventions

R1: Reference Product X DRUG

under fasted conditions

Part 1: R1-T2-T4-T1-T3; Part 1: T1-T4-T2-T3-R1; Part 1: T2-T1-T3-R1-T4; Part 1: T3-R1-T1-T4-T2; Part 1: T4-T3-R1-T2-T1

T1: Test Product M DRUG

under fasted conditions

Part 1: R1-T2-T4-T1-T3; Part 1: T1-T4-T2-T3-R1; Part 1: T2-T1-T3-R1-T4; Part 1: T3-R1-T1-T4-T2; Part 1: T4-T3-R1-T2-T1

T2: Test Product N DRUG

under fasted conditions

Part 1: R1-T2-T4-T1-T3; Part 1: T1-T4-T2-T3-R1; Part 1: T2-T1-T3-R1-T4; Part 1: T3-R1-T1-T4-T2; Part 1: T4-T3-R1-T2-T1

T3: Test Product O DRUG

under fasted conditions

Part 1: R1-T2-T4-T1-T3; Part 1: T1-T4-T2-T3-R1; Part 1: T2-T1-T3-R1-T4; Part 1: T3-R1-T1-T4-T2; Part 1: T4-T3-R1-T2-T1

T4: Test Product O DRUG

under fed conditions

Part 1: R1-T2-T4-T1-T3; Part 1: T1-T4-T2-T3-R1; Part 1: T2-T1-T3-R1-T4; Part 1: T3-R1-T1-T4-T2; Part 1: T4-T3-R1-T2-T1

R2: Reference Product Y DRUG

under fasted conditions

Part 2: R2-T7-T6-T5; Part 2: T5-T6-T7-R2; Part 2: T6-T5-R2-T7; Part 2: T7-R2-T5-T6

T5: Test Product P DRUG

under fasted conditions

Part 2: R2-T7-T6-T5; Part 2: T5-T6-T7-R2; Part 2: T6-T5-R2-T7; Part 2: T7-R2-T5-T6

T6: Test Product P DRUG

under fed conditions

Part 2: R2-T7-T6-T5; Part 2: T5-T6-T7-R2; Part 2: T6-T5-R2-T7; Part 2: T7-R2-T5-T6

T7: Test Product Q DRUG

under fasted conditions

Part 2: R2-T7-T6-T5; Part 2: T5-T6-T7-R2; Part 2: T6-T5-R2-T7; Part 2: T7-R2-T5-T6

R3: Reference Product Z DRUG

under fasted conditions

Part 3: R3-T10-T9-T8; Part 3: T10-R3-T8-T9; Part 3: T8-T9-T10-R3; Part 3: T9-T8-R3-T10

T8: Test Product S DRUG

under fasted conditions

Part 3: R3-T10-T9-T8; Part 3: T10-R3-T8-T9; Part 3: T8-T9-T10-R3; Part 3: T9-T8-R3-T10

T9: Test Product S DRUG

under fed conditions

Part 3: R3-T10-T9-T8; Part 3: T10-R3-T8-T9; Part 3: T8-T9-T10-R3; Part 3: T9-T8-R3-T10

T10: Test Product U DRUG

under fasted conditions

Part 3: R3-T10-T9-T8; Part 3: T10-R3-T8-T9; Part 3: T8-T9-T10-R3; Part 3: T9-T8-R3-T10

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy male subjects according to the assessment of the investigator, as based on a complete medical history including a physical examination, vital signs (Blood pressure (BP), Pulse rate (PR)), 12-lead Electrocardiogram (ECG), and clinical laboratory tests
• Age of 18 to 55 years (inclusive) at the time of signing informed consent
• Body mass index (BMI) of 18.5 to 29.9 kg/m2 (inclusive) at the time of signing informed consent
• Signed and dated written informed consent prior to admission to the study, in accordance with Good Clinical Practice (GCP) and local legislation
• Subjects who are sexually active must use with their partner, highly effective contraception from the time of administration of trial medication until 30 days after administration of trial medication. Adequate methods are:
• Condoms plus use of hormonal contraception by the female partner that started at least 2 months prior to administration of trial medication (e.g., implants, injectables, combined oral or vaginal contraceptives, intrauterine device) or
• Condoms plus surgical sterilization (vasectomy at least 1 year prior to enrolment) or
• Condoms plus surgically sterilised partner (including hysterectomy) or
• Condoms plus intrauterine device or
• Condoms plus partner of non-childbearing potential (including homosexual men) Subjects are required to use condoms to prevent unintended exposure of the partner (both, male and female) to the study drug via seminal fluid. Male subjects should use a condom throughout the study and for 30 days after last Investigational Medicinal Product (IMP) administration. Alternatively, true abstinence is acceptable when it is in line with the subject's preferred and usual lifestyle. If a subject is usually not sexually active but becomes active with their partner, they must comply with the contraceptive requirements detailed above.
• Male subjects should not donate sperm for the duration of the study and for at least 30 days after last IMP administration.

You may not qualify if:

• Any finding in the medical examination (including Blood pressure (BP), Pulse rate (PR) or Electrocardiogram (ECG)) deviating from normal and assessed as clinically relevant by the investigator
• Repeated measurement of systolic blood pressure outside the range of 100 to 140 mmHg, diastolic blood pressure outside the range of 60 to 90 mmHg, or pulse rate outside the range of 40 to 100 bpm at screening and pre-dose of first period
• Any laboratory value outside the reference range that the investigator considers to be of clinical relevance
• Any evidence of a concomitant disease assessed as clinically relevant by the investigator, including not resolved post-vaccination reactions
• Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological, dermatological or hormonal disorders
• Cholecystectomy or other surgery of the gastrointestinal tract that could interfere with the pharmacokinetics of the trial medication (except appendectomy or simple hernia repair, unless within the last 12 months)
• Diseases of the central nervous system (including but not limited to any kind of seizures or stroke), and other relevant neurological or psychiatric disorders

Sponsors & Collaborators

• Boehringer Ingelheim: lead

Study Sites (1)

Quotient Sciences

Nottingham, NG11 6JS, United Kingdom

Location

Related Links

• Related Info

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: Study in up to three parts: Trial part 1: five-period crossover Optional trial part 2: four-period crossover Optional trial part 3: four-period crossover

Study Record Dates

• First Submitted: June 14, 2021
• First Posted: June 15, 2021
• Study Start: July 1, 2021
• Primary Completion: February 7, 2022
• Study Completion: February 7, 2022
• Last Updated: December 9, 2022

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)