NCT04923386

Brief Summary

To determine if patients with a history of Diabetes Mellitus Type I or II developed a change in blood glucose levels as reported on Continuous glucose monitoring devices (CGMS) within the first week following administration of each dose of the COVID-19 vaccine.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
25

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jun 2021

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 6, 2021

Completed
5 days until next milestone

First Posted

Study publicly available on registry

June 11, 2021

Completed
4 days until next milestone

Study Start

First participant enrolled

June 15, 2021

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 15, 2021

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2022

Completed
Last Updated

August 17, 2022

Status Verified

August 1, 2022

Enrollment Period

6 months

First QC Date

June 6, 2021

Last Update Submit

August 15, 2022

Conditions

Keywords

mRNA VaccineHyperglycemiaHypoglycemiaDiabetes Mellitus, Type 2Diabetes Mellitus, Type 1COVID-19 Vaccine

Outcome Measures

Primary Outcomes (1)

  • Change in AUC glucose level above expected baseline

    Change in area under the curve glucose level above expected baseline

    7 days

Secondary Outcomes (2)

  • Change in peak glucose level above expected baseline

    7 days

  • Change in fasting blood glucose levels above expected baseline

    7 days

Study Arms (1)

Diabetics who receive mRNA COVID-19 vaccine

Patients that have a history of Diabetes Mellitus Type I or Type II who received Pfizer-N-Biotech or Moderna mRNA COVID-19 vaccines

Other: None (not interventional)

Interventions

This is not an intervention

Diabetics who receive mRNA COVID-19 vaccine

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All eligible patients in the PI's database.

You may qualify if:

  • Clinical diagnosis of Diabetes Mellitus Type I or Type II
  • Received the Moderna COVID-19 vaccine or Pfizer-BioNTech COVID-19 vaccine

You may not qualify if:

  • Patients \<18y/o.
  • Patients that did not receive a COVID-19 vaccine.
  • Patients who did not have a CGMS downloaded for a week prior and a week after vaccination.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

East Coast Medical Associates

Boca Raton, Florida, 33433, United States

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2Diabetes Mellitus, Type 1HyperglycemiaHypoglycemia

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesAutoimmune DiseasesImmune System Diseases

Study Officials

  • David I Levenson, M.D.

    East Coast Medical Associates

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
INDIV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

June 6, 2021

First Posted

June 11, 2021

Study Start

June 15, 2021

Primary Completion

December 15, 2021

Study Completion

February 1, 2022

Last Updated

August 17, 2022

Record last verified: 2022-08

Data Sharing

IPD Sharing
Will not share

No IPD will be shared.

Locations