Metabolic Syndrome and Degenerative Meniscus Lesions Related Knee Function

NCT04921202 | Completed DMC

• 1 other identifier: Jinzhou Medical University
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

Studies have suggested that Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis. However, no studies demonstrate the relationship between obese patients with metabolic syndrome and degenerate meniscus lesions and its knee function.The aim is to detect the correlation between obese patients with metabolic syndrome and degenerate meniscus injuries.

Conditions

Metabolic Syndrome; Meniscus Lesion; Obesity, Abdominal; Knee Arthritis

Keywords

Metabolic Syndrome; degenerate meniscus lesions; obesity; knee function

Outcome Measures

Primary Outcomes (2)

• the Knee injury and Osteoarthritis Outcome Score (KOOS) total

  The Knee injury and Osteoarthritis Outcome Score (KOOS) holds five subscales including: Pain (9 items); other Symptoms (7 items); Activities of Daily Living (ADL, 17 items); Sport and Recreation function (Sport/Rec, 5 items); and knee-related Quality of Life (QoL, 4 items). Each subscale is scored separately from zero (extreme knee problems) to 100 (no knee problems).

  up to 12 month

• The International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) score

  The International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) score to determine the meniscus function. The IKDC is a questionnaire that has high reliability and validity for patients with a meniscal tear\[36, 37\] \[38\]. The questionnaire contains 18 items (7 items for symptoms, 1 item for sport activity, 9 items for daily activities, and 1 item for current knee function.) The total score is transformed to a value on a scale of 0 to 100, with 100 representing the highest knee function and 0 is the worst.

  up to 12 month

Secondary Outcomes (6)

• KOOS Pain subscale

  up to 12 month

• Symptoms subscale

  up to 12 month

• Activities of Daily Living subscale

  up to 12 month

• Sport and Recreation function subscale

  up to 12 month

• knee-related Quality of Life subscale

  up to 12 month

Study Arms (2)

without metabolic syndrome and BMI<24

100 volunteers aged between 35-70 years old with body mass index(BMI)\<24 without Metabolic syndrome

Metabolic Syndrome with BMI>27

80 Metabolic syndrome patients with BMI\>27 were included in the study

Other: Metabolic syndrome and meniscus injuries

Interventions

Metabolic syndrome and meniscus injuries OTHER

Metabolic syndrome

Metabolic Syndrome with BMI>27

Eligibility Criteria

• Age: 35 Years - 70 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

participants from Jinzhou City, west of Liaoning Province

You may qualify if:

• Must be age between 35 and 70 years old;
• Clinical diagnosis of metabolic syndrome;
• BMI score more than 27 or less than 24
• Clinical diagnosis of 3 grade degneration meniscus leisons;

You may not qualify if:

• Must be able to have no acute knee injury such as car crash or acute sports injury;
• Must be able to have no knee surgeries history;
• Must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity;
• Must be able to have no contraindications to MRI;
• Must be able to have no severe cardiopulmonary disease;
• Must be able to have no musculoskeletal or neuromuscular impairments ;
• Must be able to have good visual, hearing, or cognitive;

Sponsors & Collaborators

• The First People's Hospital of Jingzhou: lead

Study Sites (1)

First Affiliated Hospital of Jinzhou Medical University

Jinzhou, Liaoning, 121000, China

Location

MeSH Terms

Conditions

Metabolic Syndrome; Obesity, Abdominal; Obesity

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Hongyu Wang, Doctor

  The First People's Hospital of Jingzhou

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: chief residents

Study Record Dates

• First Submitted: June 3, 2021
• First Posted: June 10, 2021
• Study Start: June 1, 2017
• Primary Completion: March 25, 2020
• Study Completion: March 1, 2021
• Last Updated: June 10, 2021

Record last verified: 2021-06

Locations

CN (1)