Mold Exposure and Impact on Asthma Control in French Asthmatic Children
CHAMPIASTHMA
Assessment of Mold Exposure in Asthmatic Children Follow-up in Nord and Pas-De-Calais Departments, France, and Impact on Asthma Control
2 other identifiers
observational
451
1 country
10
Brief Summary
Observational, multicenter, study conducted in 12 hospitals in the Nord and Pas-De-Calais departments. The aim of this study is to describe the relationship between reported exposure to molds and asthma control in a pediatric population. Each patient followed by a specialized asthma pediatrician in one of the study center will be proposed to participate in the study. Children aged 1 to \< 18 years, with asthma diagnosis, based on the assessment of a specialized physician after a follow-up of at least 6 months Inclusion, non-inclusion and exclusion criteria will be verified by the investigators. The questionnaires will be completed during the consultation, collected by the physician in charge of the consultation and sent to the principal investigator for data entry. Inclusion will take place over a period of 12 consecutive months from the date of obtaining regulatory approval.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2020
10 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 10, 2020
CompletedFirst Submitted
Initial submission to the registry
June 2, 2021
CompletedFirst Posted
Study publicly available on registry
June 8, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 20, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
August 20, 2021
CompletedApril 22, 2026
March 1, 2022
1.2 years
June 2, 2021
April 17, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Asthma control according to GINA guidelines
The Global Initiative for Asthma (GINA)guidelines: Well controlled Partly controlled Uncontrolled
At the time of inclusion
Secondary Outcomes (8)
Asthma control according to Asthma Control Test (ACT) score in children aged 12 years and older: Controlled if ACT ≥ 20
At the time of inclusion
Asthma control according to pACT score in children aged 1 to 11 years old: Controlled if ACT ≥ 20
At the time of inclusion
Asthma treatment step according to GINA guidelines: Step 1 to step 4 in children aged < 6 years Step 1 to step 5 in children aged ≥ 6 years
At the time of inclusion
Inhaled corticosteroid doses in µg/day of fluticasone
At the time of inclusion
Acute asthma events in the past 12 months
At the time of inclusion
- +3 more secondary outcomes
Study Arms (2)
Asthma patients unexposed to mold / moisture
No mold / moisture exposure is defined by a negative response to all of the 5 following questions, asked in the form of a parent-completed declarative questionnaire regarding the child's primary living home.
Asthma patients exposed to mold / moisture
Mold / moisture exposure is defined by a positive response to at least one of the 5 following questions, asked in the form of a parent-completed declarative questionnaire regarding the child's primary living home.
Interventions
Mold / moisture exposure is assessed by the 5 following questions, whose positive response has been associated with the actual presence of mold in the household (according to data from the literature data), asked in the form of a parent-completed declarative questionnaire regarding the child's primary living home: * Presence of visible mold * Impression of dampness * Apparent dampness * Existence of recent water damage in the last year * Presence of a moldy odor
Eligibility Criteria
Children follow-up by a specialized asthma pediatrician in secondary (general hospital) and tertiary care (Lille university hospital) centers.
You may not qualify if:
- Children living ≤ 50% of the weekly time in their primary home (e.g., shared custody)
- Children whose living arrangement characteristics are difficult to analyze (e.g., child accompanied by grandparents or by the parent without primary custody)
- Children whose residence has recently changed, making it impossible to assess the impact of the living arrangement over the past year
- Children living outside of the Nord and Pas-de-Calais departments
- Children whose parents are unable to complete the questionnaire
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (10)
Ch Armentieres
Armentières, France
Ch Boulogne-Sur-Me
Boulogne-sur-Mer, 62321, France
Ch Calais
Calais, France
CH Dunkerque
Dunkirk, 59385, France
Centre Hospitalier de Lens
Lens, France
Hop Jeanne de Flandre Chu Lille
Lille, 59037, France
Centre Hospitalier St Vincent
Lille, France
Centre hospitalier de Roubaix
Roubaix, France
Centre Hospitalier de Seclin
Seclin, France
Centre Hospitalier,
Valenciennes, France
Related Publications (1)
Sauvere M, Lejeune S, Chagnon F, Drumez E, Cisterne C, Mordacq C, Thumerelle C, Scalbert M, Le Mee A, Amani M, El Mourad S, Enchery S, Pouessel G, Roussel J, Dartus M, Behal H, Deschildre A. Home exposure to moisture and mold is associated with poorer asthma control in children: CHAMPIASTHMA study. J Allergy Clin Immunol Glob. 2025 Jan 17;4(2):100415. doi: 10.1016/j.jacig.2025.100415. eCollection 2025 May.
PMID: 40130077RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Antoine DESCHILDRE, MD,PhD
University Hospital, Lille
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 2, 2021
First Posted
June 8, 2021
Study Start
June 10, 2020
Primary Completion
August 20, 2021
Study Completion
August 20, 2021
Last Updated
April 22, 2026
Record last verified: 2022-03