The Burden of COVID-19 Survivorship
1 other identifier
interventional
27
1 country
1
Brief Summary
This research study is being done to find out what the longer-term physiological consequences of COVID-19 are, and to determine if exercise therapy can help improve lung function, heart function and overall fitness, and reduce symptoms in people recovering from SARS-CoV-2.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable covid19
Started Nov 2021
Longer than P75 for not_applicable covid19
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 31, 2021
CompletedFirst Posted
Study publicly available on registry
June 4, 2021
CompletedStudy Start
First participant enrolled
November 4, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2024
CompletedMarch 28, 2025
March 1, 2025
2.2 years
May 31, 2021
March 27, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Maximal oxygen update (VO2max) measured in mL/kg/min
VO2max is the maximal oxygen consumed during an exhaustive exercise test
8 weeks
Secondary Outcomes (7)
Peak exercise work rate (Wpeak) measured in Watts
8 weeks
Forced vital capacity (FVC) measured in L
8 weeks
Forced expiratory volume in 1 second (FEV1) measured in L
8 weeks
Maximal inspiratory pressure (MIP) measured in cmH2O
8 weeks
Maximal expiratory pressure (MEP) measured in cmH2O
8 weeks
- +2 more secondary outcomes
Study Arms (2)
Control Group
NO INTERVENTIONStandard physician-guided medical care after COVID-19
Interventional (exercise training) Group
EXPERIMENTAL8 week home-based exercise training
Interventions
8 week home-based exercise therapy 4-5 times/week
Eligibility Criteria
You may qualify if:
- Aged 21 to 75 years.
- History of RT-PCR proven SARS-CoV-2 infection.
- Deemed 'recovered' from SARS-CoV-2 infection.
- Not clinically obese (BMI ≥ 36) and/or suffer from musculoskeletal or other conditions that would limit exercise participation.
- No evidence of cardiac ischemia at rest or during exertion (via ECG).
- Able to provide written informed consent.
You may not qualify if:
- Individuals less than 21 or more than 75 years old.
- Not able to take part in structured exercise training due to injury or other conditions that would put person at risk during exercise.
- Unable to provide written informed consent.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Mayo Cliniclead
Study Sites (1)
Mayo Clinic in Florida
Jacksonville, Florida, 32224, United States
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Bryan Taylor, PhD
Mayo Clinic
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
May 31, 2021
First Posted
June 4, 2021
Study Start
November 4, 2021
Primary Completion
December 31, 2023
Study Completion
December 31, 2024
Last Updated
March 28, 2025
Record last verified: 2025-03
Data Sharing
- IPD Sharing
- Will not share