Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol

NCT04912089 | Completed Results

• 1 other identifier: 210686
• Study Type: interventional
• Target: 73
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to a high dose, low dose, or assessment only condition. Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.

Conditions

Anxiety Disorders; Depression; Posttraumatic Stress Disorder

Outcome Measures

Primary Outcomes (1)

• Change in Cognitive Performance

  Span Working Memory Score. Scores are calculated based on memory accuracy total points across all trials, with higher scores indicating better performance (0-81 range).

  Baseline, Week 4

Secondary Outcomes (16)

• Change in Reading Span Blood Oxygen Level Dependent (BOLD) Response

  Baseline, Week 4

• Change in Emotional Working Memory Blood Oxygen Level Dependent (BOLD) Response

  Week 4

• Change in Neuropsychological Performance

  Baseline, Week 4

• Anxiety Symptoms

  Baseline, Week 4

• Symptoms of Depression

  Baseline, Week 4

Study Arms (3)

Cognitive Training Low Dose

EXPERIMENTAL

Cognitive training completed for 8 sessions

Behavioral: COGENT

Cognitive Training High Dose

EXPERIMENTAL

Cognitive training completed for 16 sessions

Behavioral: COGENT

Repeat Assessment

NO INTERVENTION

Interventions

COGENT BEHAVIORAL

COGENT is based on a working memory capacity task, which requires individuals to memorize stimuli while simultaneously completing a secondary puzzle task.

Cognitive Training High Dose; Cognitive Training Low Dose

Eligibility Criteria

• Age: 21 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• age 21-55
• fluent in English
• diagnosis of mood, anxiety, or traumatic stress disorder
• clinically elevated repetitive negative thinking
• outpatient status
• week stability if taking selective serotonin reuptake inhibitor (SSRI) medications

You may not qualify if:

• past year diagnosis of severe alcohol or moderate or greater substance use disorder
• lifetime history of psychotic or bipolar I disorder
• acute suicidality necessitating immediate clinical intervention
• neurodegenerative or neurodevelopmental disorders
• history of moderate or severe traumatic brain injury or other known neurological condition
• sensory deficits that would preclude completing tasks
• conditions unsafe for completing MRI scanning (e.g., metal in body)
• currently receiving psychosocial treatment
• currently receiving psychiatric pharmacotherapy, except SSRIs

Sponsors & Collaborators

• University of California, San Diego: lead

Study Sites (1)

UC San Diego

San Diego, California, 92037, United States

Location

MeSH Terms

Conditions

Anxiety Disorders; Depression; Stress Disorders, Post-Traumatic

Interventions

cogent db

Condition Hierarchy (Ancestors)

Mental Disorders; Behavioral Symptoms; Behavior; Stress Disorders, Traumatic; Trauma and Stressor Related Disorders

Results Point of Contact

• Title: Jessica Bomyea
• Organization: UC San Diego

jbomyea@health.ucsd.edu

858-822-1470

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 28, 2021
• First Posted: June 3, 2021
• Study Start: October 15, 2021
• Primary Completion: May 31, 2023
• Study Completion: June 30, 2023
• Last Updated: July 23, 2025
• Results First Posted: July 23, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)