NCT04901624

Brief Summary

Repeat testing for SARS-CoV-2 antibodies in disadvantaged communities will help identify active and recovered infections over time, and as more is understood about antibody protection, it may help identify persons who have immunity. Many questions about social barriers and behavioral facilitators remain unanswered. This project aims to evaluate the effectiveness of risk-based messaging and incentives that promote repeated testing for SARS-CoV-2 antibodies, as well as to understand social and behavioral determinants of COVID-19 testing and variations within sub-groups of this population.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,164

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2021

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 29, 2021

Completed
2 months until next milestone

First Posted

Study publicly available on registry

May 25, 2021

Completed
1 month until next milestone

Study Start

First participant enrolled

June 29, 2021

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 3, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 3, 2023

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

August 14, 2024

Completed
Last Updated

August 14, 2024

Status Verified

July 1, 2024

Enrollment Period

1.9 years

First QC Date

March 29, 2021

Results QC Date

June 3, 2024

Last Update Submit

July 22, 2024

Conditions

Keywords

antibodies

Outcome Measures

Primary Outcomes (1)

  • Attendance Rate at Time 2 SARS-CoV-2 Antibody Test

    Effectiveness of risk-based messaging and incentives to encourage attendance at Time 2 testing for SARS-CoV-2 antibodies

    6 months

Secondary Outcomes (1)

  • Social and Behavioral Determinants of Antibody Testing

    6 months

Study Arms (4)

Personal Risk + Loss Protection

EXPERIMENTAL

Personal Risk + Loss Protection

Behavioral: Personal Risk MessagingBehavioral: Loss Protection

Personal Risk + Lottery Incentive

EXPERIMENTAL

Personal Risk + Lottery Incentive

Behavioral: Personal Risk MessagingBehavioral: Lottery Incentive

Family Risk + Loss Protection

EXPERIMENTAL

Family Risk + Loss Protection

Behavioral: Family Risk MessagingBehavioral: Loss Protection

Family Risk + Lottery Incentive

EXPERIMENTAL

Family Risk + Lottery Incentive

Behavioral: Family Risk MessagingBehavioral: Lottery Incentive

Interventions

Family risk framing may engender concern for loved ones. It may also make it easier to mentally simulate family burdens with COVID-19 such as knowing how several people in the family becoming sick could adversely affect the lives of everyone in the family. Households randomized to family risk messaging will receive the following message: "Antibody testing will help you understand your family's risk of getting COVID-19."

Family Risk + Loss ProtectionFamily Risk + Lottery Incentive

Personal risk framing may engender concern for oneself. Households randomized to personal risk messaging will receive the following message: "Antibody testing will help you understand your risk of getting COVID-19."

Personal Risk + Loss ProtectionPersonal Risk + Lottery Incentive
Loss ProtectionBEHAVIORAL

Household members are offered a baseline incentive with a 90% (9 in 10) chance of $60 and receive insurance on winning the baseline incentive for repeat antibody testing.

Family Risk + Loss ProtectionPersonal Risk + Loss Protection

Household members are offered a baseline incentive with a 90% (9 in 10) chance of $60 and receive a bonus lottery incentive with a 4 small (1 in 25) chance of winning $150 for repeat antibody testing.

Family Risk + Lottery IncentivePersonal Risk + Lottery Incentive

Eligibility Criteria

Age5 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Adults and children 5 years of age and older

You may not qualify if:

  • Children under 5 years of age

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

AltaMed Health

Los Angeles, California, 90022, United States

Location

Related Publications (1)

  • Doctor JN, Berg AH, Knight TK, Kadono M, Stewart E, Sonik R, Hochman M, Sood N. Cross-sectional study examining household factors associated with SARS-CoV-2 seropositivity in low-income children in Los Angeles. BMJ Open. 2023 May 31;13(5):e070291. doi: 10.1136/bmjopen-2022-070291.

Results Point of Contact

Title
Dr. Jason Doctor
Organization
University of Southern California

Study Officials

  • Jason Doctor, PhD

    University of Southern California

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

March 29, 2021

First Posted

May 25, 2021

Study Start

June 29, 2021

Primary Completion

June 3, 2023

Study Completion

June 3, 2023

Last Updated

August 14, 2024

Results First Posted

August 14, 2024

Record last verified: 2024-07

Locations