Effects of Eccentric Pedaling at Different Rates on Neuromuscular Function

NCT04886115 | Recruiting

• 1 other identifier: LAROCHE 2021
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

The recent appearance of ergocycles that can be used for eccentric pedaling (Cyclus type) has aroused a growing interest in the field of rehabilitation. The mechanical, metabolic, and cardiorespiratory characteristics of eccentric exercises make them an exercise of choice when the goal is to improve locomotor muscle function and exercise capacity. Despite its potential advantages, the optimal modalities of eccentric pedaling, in particular the choice of pedaling frequency, are still poorly understood, especially its effects on the neuromuscular system. Indeed, most training protocols impose a fixed pedaling power but with highly variable pedaling rates, ranging from 15 to 60 rpm (Besson et al., 2013; MacMillan et al., 2017). For a given pedaling power level (P), the choice of pedaling frequency (F) directly impacts the force torque (C) and thus the force applied to the pedals, since power is equal to the product of pedaling frequency and force torque (P = F.C). For frequencies varying from 15 to 60 rpm, the level of muscular tension during pedaling therefore varies from single to quadruple. These very large variations in force can influence the neuromuscular adaptations induced during a prolonged training period. For example, the use of low pedaling frequencies corresponding to high muscle tension could favor peripheral muscular adaptations (e.g. contractility) whereas higher pedaling frequencies could favor central (i.e. nervous) adaptations. A better understanding of the neuromuscular adaptations induced by a period of eccentric pedaling at different cadences will allow for a more precise definition of training protocols for populations likely to undergo this type of training (e.g. elderly people, patients with heart failure).

Conditions

Volunteers Who Can do Moderate Physical Activity

Outcome Measures

Primary Outcomes (1)

• Maximum isometric force developed in the quadriceps

  6 weeks of training

Study Arms (3)

Eccentric pedalling group at 15 rpm

EXPERIMENTAL

Other: Neuromuscular evaluation; Other: Assessment of aerobic capacity, muscle architecture and habituation to the eccentric pedaling task; Other: Pedaling at 15 rpm

Eccentric pedalling group at 60 rpm

EXPERIMENTAL

Other: Neuromuscular evaluation; Other: Assessment of aerobic capacity, muscle architecture and habituation to the eccentric pedaling task; Other: Pedaling at 60rpm

Control

ACTIVE COMPARATOR

Other: Neuromuscular evaluation; Other: Assessment of aerobic capacity, muscle architecture and habituation to the eccentric pedaling task; Other: No pedaling, usual activity

Interventions

Neuromuscular evaluation OTHER

Before and after training. Muscle function: * voluntary maximal isometric force of the knee extensors * evoked force in the knee extensors by double percutaneous electrical stimulation at 100 and 10 Hz * level of voluntary activation * voluntary maximum force in concentric and eccentric mode at an angular speed of 60°.s-1 * squat jump and counter-movement jump

Control; Eccentric pedalling group at 15 rpm; Eccentric pedalling group at 60 rpm

Assessment of aerobic capacity, muscle architecture and habituation to the eccentric pedaling task OTHER

Before and after training. Cardiovascular-respiratory function: * Oxygen consumption during the incremental concentric pedaling test conducted to high effort perception. * heart rate during pedaling tasks Muscle architecture: \- Pennation angle and thickness of vastus lateralis, rectus femoris, gastrocnemius medialis and lateralis muscles, before and after training. Familiarization with eccentric pedaling

Control; Eccentric pedalling group at 15 rpm; Eccentric pedalling group at 60 rpm

Pedaling at 15 rpm OTHER

3 training sessions per week for 6 weeks

Eccentric pedalling group at 15 rpm

No pedaling, usual activity OTHER

Maintain usual physical activity and diet for a period of 6 weeks.

Control

Pedaling at 60rpm OTHER

3 sessions per week of training for 6 weeks

Eccentric pedalling group at 60 rpm

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Person who has given oral consent
• Subject capable of understanding simple commands and giving consent
• Subject (male or female) between 18 and 40 years of age.
• Subject able to do moderate physical activity

You may not qualify if:

• Person not affiliated to national health insurance.
• Physical disabilities affecting the lower limbs or the pelvis, and which may hinder or prevent the practice of exercise on an ergocycle, whether neurological (central or peripheral), arterial (in particular, arterial disease of the lower limbs with a systolic index \< 0.6) or orthopedic (degenerative or inflammatory rheumatism).
• Person under legal protection (curatorship, guardianship)
• Person under court order (sauvegarde de justice)
• Pregnant, parturient or breastfeeding women
• Major unable to express consent
• Minor

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

Chu Dijon Bourgogne

Dijon, 21000, France

RECRUITING

Central Study Contacts

Davy LAROCHE

CONTACT

03 80 29 56 65; davy.laroche@chu-dijon.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 10, 2021
• First Posted: May 13, 2021
• Study Start: February 7, 2022
• Primary Completion: June 1, 2025
• Study Completion: June 1, 2025
• Last Updated: February 20, 2024

Record last verified: 2024-02

Locations

FR (1)