The Relationship Between HLA Tissue Compatibility and Biliary Complications in Patients With Liver Transplantation

NCT04885582 | Completed DMC

• 1 other identifier: 2017/133
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Liver transplantation has become the accepted treatment option for advanced liver failure in recent years. In addition to the increase in the number of centers performing transplant and the decrease in complication rates depending on the experience gained, the most common biliary complications did not improve at the desired level. For this reason, studies in this field are frequent today. The structural complexities of HLA antigens have been the subject of investigation in recent years. With the development of DNA and RNA amplification methods; It is increasingly difficult for physicians to keep up with the increasing burden of knowledge regarding the genetic aspects of these antigens. Concrete benefits of this gene complex, which has been investigated in various fields and preserves its mystery, have not been determined in liver transplant patients. However, there are publications showing its connection with the bile epithelium in liver transplantation and its relationship with the disappearing bile duct syndrome. In this study, our aim is to explain whether the bile duct complications, which appear like a continuous wall and can lead to frightening pictures, are related to HLA tissue compatibility.

Conditions

Liver Transplant; Complications; HLA Antigens

Keywords

Liver Transplant; Complications; HLA; biliary fistula; biliary stricture

Outcome Measures

Primary Outcomes (1)

• Bliary complications

  Biliary fistüla, biliary stenosis

  2 years

Study Arms (2)

Patients with biliary complications

patients with postoperative biliary fistula, biliary stenosis

Other: HLA antigen results

Patients without biliary complications

patients without postoperative biliary fistula and biliary stenosis

Other: HLA antigen results

Interventions

HLA antigen results OTHER

HLA-A, HLA-B, HLA-DR tissue matching results in both groups will be compared.

Patients with biliary complications; Patients without biliary complications

Eligibility Criteria

• Age: 1 Year - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who had liver transplantation and HLA tissue tests between 2017 and 2019 at Inonu University liver transplant institute

You may qualify if:

• patients with liver transplantation and tested for HLA antigen (recipient - donor)

You may not qualify if:

• patients who died early Patients whose HLA antigen is not checked

Sponsors & Collaborators

• Inonu University: lead

Study Sites (1)

Health science University - Kayseri State Hospital

Kocasinan, Kayseri, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Biliary Fistula

Condition Hierarchy (Ancestors)

Digestive System Fistula; Digestive System Diseases; Fistula; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc Prof

Study Record Dates

• First Submitted: May 11, 2021
• First Posted: May 13, 2021
• Study Start: May 10, 2017
• Primary Completion: May 10, 2019
• Study Completion: May 20, 2020
• Last Updated: May 13, 2021

Record last verified: 2021-05

Locations

TU (1)