Investigation of the Characteristics of Chronic Pain Developing After COVID-19

NCT04883216 | Completed

• 1 other identifier: 2021/389
• Study Type: observational
• Target: 776
• Locations: 1 country
• Sites: 1

Brief Summary

Data on pain after COVID-19 were generally collected from hospitalized patients and only include information on acute pain conditions. However, the characteristics of the chronic pain experienced after COVID-19 are unknown. For this reason, the treatment and recommendations for patients who present with chronic pain after COVID-19 are not clear. Our goal is to determine the characteristics and risk factors of chronic pain developing in COVID-19 patients and to create specific treatment recommendations for these patient groups with further studies.

Conditions

Covid19; Coronavirus; Chronic Pain

Keywords

Chronic Pain; COVID19; Characteristics

Outcome Measures

Primary Outcomes (5)

• Self-Leeds Assessment of Neuropathic Symptoms & Signs (S-LANSS) Pain Score

  The S-LANSS aims to identify pain of predominantly neuropathic origin, as distinct from nociceptive pain, without the need for clinical examination.

  up to 1 year

• The Hospital Anxiety and Depression Scale (HADS) Score

  The Hospital Anxiety and Depression Scale (HADS) is a self-assessment questionnaire that has been found to be a reliable instrument for detecting states of anxiety and depression in the setting of hospital outpatient clinic. The HADS questionnaire has seven items each for depression and anxiety subscales.

  up to 1 year

• Central Sensitization Inventory (CSI)

  The Central Sensitisation Inventory (CSI) is a self-report outcome measure designed to identify patients who have symptoms that may be related to central sensitisation (CS) or central sensitivity syndromes (CSS) such as fibromyalgia, neck injury, temporomandibular joint disorder or migraine/tension headaches. CSI includes 25 questions related to common CSS symptoms.

  up to 1 year

• Self-report Demographic Questionnaire

  A questionnaire made by the researchers to understand the demographic characteristics of the patients included.

  up to 1 year

• Visual Analog Scale (VAS) for Pain

  The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between "no pain" and "worst pain."

  up to 1 year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1120 patients who had previously suffered from COVID-19 disease will be included in the study upon application to physical medicine and rehabilitation outpatient clinics with pain complaints developed after COVID-19.

You may qualify if:

• Being over the age of 18
• SARS-CoV-2 infection demonstrated with the PCR test (testing date irrelevant)
• Pain developed or increased after having COVID-19

You may not qualify if:

• \. Mental retardation or mental status not eligible to answer the questionnaires

Sponsors & Collaborators

• Istanbul University: lead

Study Sites (1)

Istanbul University Istanbul Faculty of Medicine

Istanbul, 34093, Turkey (Türkiye)

Location

Related Publications (4)

• Weng LM, Su X, Wang XQ. Pain Symptoms in Patients with Coronavirus Disease (COVID-19): A Literature Review. J Pain Res. 2021 Jan 26;14:147-159. doi: 10.2147/JPR.S269206. eCollection 2021.

  PMID: 33531833 BACKGROUND

• Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, Rubin GJ. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet. 2020 Mar 14;395(10227):912-920. doi: 10.1016/S0140-6736(20)30460-8. Epub 2020 Feb 26.

  PMID: 32112714 BACKGROUND

• Ding Y, He L, Zhang Q, Huang Z, Che X, Hou J, Wang H, Shen H, Qiu L, Li Z, Geng J, Cai J, Han H, Li X, Kang W, Weng D, Liang P, Jiang S. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J Pathol. 2004 Jun;203(2):622-30. doi: 10.1002/path.1560.

  PMID: 15141376 BACKGROUND

• Eccles R. Understanding the symptoms of the common cold and influenza. Lancet Infect Dis. 2005 Nov;5(11):718-25. doi: 10.1016/S1473-3099(05)70270-X.

  PMID: 16253889 BACKGROUND

MeSH Terms

Conditions

COVID-19; Coronavirus Infections; Chronic Pain

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Ayşegül Ketenci, Professor

  Professor

  STUDY DIRECTOR

• Mert Zure, Expert

  MD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: May 9, 2021
• First Posted: May 12, 2021
• Study Start: March 24, 2021
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: April 19, 2022

Record last verified: 2022-04

Locations

TU (1)